Analysis of induced tooth movement in rats: Influence of alendronate on root resorptions, comparative studies on transverse and longitudinal sections and microscopic evaluation at different study periods

Author(s)

Ana Carolina Cuzzuol Fracalossi

• Document type: Master's Dissertation
• Press: Bauru.
• Institution: Universidade de São Paulo (USP). Faculdade de Odontologia de Bauru (FOB/SDB)
• Defense date: 2007-08-03

Examining board members

Alberto Consolaro; Marcos Rogério de Mendonça; Maria Bernadete Sasso Stuani

• Advisor: Alberto Consolaro

Abstract

Induced tooth movement in rats is a good model to investigate the induction of bone resorption and apposition in normality and in metabolic bone diseases, as well as to evaluate the effects of drugs. Thus, the first chapter addresses the influence of alendronate on the percentage of root resorptions during induced tooth movement, using the experimental model of rats on transverse sections. Alendronate is a type of bisphosphonate, a class of drugs widely used in Medicine for osteopenia control, human osteoporosis prevention, as well as for fracture prevention in postmenopausal osteoporosis. Investigations employ the experimental model of mesial inclination of the maxillary first molar. Methodological variations are observed in this experimental model in rats concerning the periods of tooth movement and sections employed for microscopic analysis. Thus, on the second chapter, the percentage and frequency of root resorptions on transverse and longitudinal sections are compared, and the ideal direction of section for investigation of induced tooth movement in rats is suggested. The biology of induced tooth movement is changed by several factors, e.g. the different study periods and directions of microscopic sections. For this reason, the third chapter comprises evaluation of tissue and cellular phenomena of induced tooth movement at study periods of three, five, seven and nine days, on transverse and longitudinal sections. (AU)