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| Author(s): |
Lucila Hernandes da Silva
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) |
| Defense date: | 2012-03-01 |
| Examining board members: |
Anselmo Sigari Moriscot;
Reury Frank Pereira Bacurau;
Marco Carlos Uchida
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| Advisor: | Elen Haruka Miyabara |
| Abstract | |
Skeletal muscles from old rats fail to completely regenerate following injury. In the present work, we hypothesized that pharmacological stimulation of b2-adrenoceptors in aged muscles following injury could improve their regenerative capacity. Young and aged rats were treated with a subcutaneous injection of b2-adrenergic agonist formoterol (2 mg/kg/day) up to 10 and 21 days after soleus muscle injury. Formoterol-treated muscles from old rats evaluated at 10 and 21 days post-injury showed reduced inflammation and regenerating myofibers of greater caliber when compared to their injured controls. Formoterol minimized the decrease in tetanic force and increased protein synthesis and mTOR phosphorylation in old muscles at 10 days post-injury. Our results suggest that formoterol improves structural and functional regenerative capacity of regenerating skeletal muscles from aged rats by increasing protein synthesis via mTOR activation. (AU) | |
| FAPESP's process: | 09/12593-0 - Effect of beta 2-adrenergic stimulation on attenuation of skeletal muscle regenerative deficit in old rats. |
| Grantee: | Lucila Hernandes da Silva |
| Support Opportunities: | Scholarships in Brazil - Master |