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| Author(s): |
Milena Fernandes de Freitas
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) |
| Defense date: | 2012-07-17 |
| Examining board members: |
Marucia Chacur;
Carolina Demarchi Munhoz de Souza;
Vanessa Olzon Zambelli
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| Advisor: | Marucia Chacur |
| Abstract | |
Chemical stimulation of nociceptive afferent fibers through the injection of different substances has been studied in different models of muscle pain in animals. Carrageenan is one of the agents that produce inflammation and is often used in models of muscle pain. Our goal is to explore in greater detail the involvement of glial cells (astrocytes and microglia), pro-inflammatory cytokines, prostanoids and nitric oxide after induction of acute myositis and correlate it with nociceptive behavioral models. It will be assessed the activity of these mediators in the spinal cord after induction of myositis in rats, using Western blotting assay. Such investigations may be a totally new approach to try to understand how some mediators are involved in this kind of pain. Thus, the data obtained in this project will elucidate the mechanisms involved in musculoskeletal pain, which are of difficult treatment and of great clinical relevance. (AU) | |
| FAPESP's process: | 09/12244-6 - Central mechanisms of musculoskeletal pain induced by carrageenin in rats. |
| Grantee: | Milena Fernandes de Freitas |
| Support Opportunities: | Scholarships in Brazil - Master |