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| Author(s): |
Miguel José Rangel Júnior
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) |
| Defense date: | 2012-08-28 |
| Examining board members: |
Newton Sabino Canteras;
Sara Joyce Shammah Lagnado;
Isabel Marian Hartmann de Quadros
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| Advisor: | Newton Sabino Canteras |
| Abstract | |
We investigated the neural systems involved in the contextual defense to a social defeat. We established a protocol to observe contextual defensive responses in animals previously defeated by an aggressive conspecific: animals were kept ten days living in a apparatus composed by two cages (room and resident cages). On the 11th day animals were exposed to an aggressive conspecific and defeated by it. On the following day, animals were exposed to the apparatus. These defeated animals presented defensive responses, characterized by risk assessment behaviors. Increased Fos expression was found in MEApd, LSr, elements of the social responsive medial hypothalamic circuit, the juxtadorsal part of the lateral hypothalamic area and the dorsal premammillary nucleus (PDMdm). The data allowed us to outline a putative circuit involved in the expression of contextual defense to social defeat, and indicates that both innate and contextual defense to social threat apparently share the same neural circuits. (AU) | |
| FAPESP's process: | 10/03741-3 - Anatomic-functional mapping of neural sites involved in the responses observed in post-defeat |
| Grantee: | Miguel José Rangel Junior |
| Support Opportunities: | Scholarships in Brazil - Master |