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| Author(s): |
Priscilla de Souza Monteiro
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) |
| Defense date: | 2012-09-28 |
| Examining board members: |
Maria Luiza Morais Barreto de Chaves;
Kátia de Angelis Lobo D'Avila;
Silvia Lacchini
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| Advisor: | Maria Luiza Morais Barreto de Chaves |
| Abstract | |
The aim of this study was to investigate hypothyroidism effects on thoracic aorta wall. For histological analyses were performed stains like hematoxilin-eosin, picrosirius and Weigert. In the protein expression assays were performed quantification for collagen I and III, elastin, MMP-9, MMP-2, TIMP-1 and TIMP-2. The histological analyses showed a decrease in aortas CSA and also a decrease in protein expression of collagen I in the hypo group. As regards to elastin, was possible to see an increase of this protein expression in hypo animals. In the evaluation for MMP-9 expression, was found a decrease in this protein and for TIMP-2 an increase in hypothyroidism group. Facing to these results, is possible to suggest that the hypometabolic state triggered by hypothyroidism, affects the VSMCs compromising mechanisms of synthesis/degradation and changing the important constitution of thoracic aorta ECM. (AU) | |
| FAPESP's process: | 10/00934-5 - Endothelial dysfunction and vascular remodeling associated to experimental hypothyroidism. Modulation of NFkB signaling pathway. |
| Grantee: | Priscilla de Souza Monteiro |
| Support Opportunities: | Scholarships in Brazil - Master |