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| Author(s): |
Giovana Giacomini
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) |
| Defense date: | 2013-02-05 |
| Examining board members: |
Jose Maria Alvarez Mosig;
Hiro Goto;
Nancy Starobinas
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| Advisor: | Jose Maria Alvarez Mosig |
| Abstract | |
Trypanosoma cruzi, the parasite responsible for Chagas´ disease, displays virulent isolates and low-virulence ones. We explored the involvement of the immune system in the low level parasitemia of mice infected with low-virulence Sylvio X10/4 parasites. C57BL/6 WT mice do not show patent parasitemias after 24 hours after infection and the parasite load revealed that most parasites go to the liver and spleen. The involvement of natural antibodies was discarded and a small participation of the complement system was suggested. However, infected IFN-<font face=\"Symbol\">gKO mice showed intermittent patent parasitemias in the first weeks of infection and this can not be attributed to deficiency in the production of acute phase proteins. Parasite-specific antibodies seem crucial for parasite control, in addition, animals that have only IgM are resistant to infection. Thus, we suggest that the rapid clearance that follows Sylvio X10/4 inoculation is an active removal process and, at the long run, not only IgG, but also IgM play an important role in protection. (AU) | |
| FAPESP's process: | 10/12324-7 - The murine infection by Trypanosoma cruzi clone Sylvio X10/4: immune system involvement in parasitaemia control |
| Grantee: | Giovana Giacomini |
| Support Opportunities: | Scholarships in Brazil - Master |