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Effect of thyroid hormone upon creatine transporter (CreaT: SLC6A8) gene expression in skeletal and cardiac muscles in rats.
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| Author(s): |
Lucas Guimarães Ferreira
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) |
| Defense date: | 2008-12-05 |
| Examining board members: |
Maria Tereza Nunes;
Ubiratan Fabres Machado;
Leonardo dos Reis Silveira
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| Advisor: | Maria Tereza Nunes |
| Abstract | |
Creatine (Cr) is a high-energy phosphate reservoir and the fastest source for intracellular ATP regeneration. The thyroid hormone plays a key role on the maintenance of basal metabolic rate, increasing the synthesis and the degradation of ATP through regulation of target-genes. In this study, we explore the effects of thyroid hormone on Cr transporter gene expression and regulation of intracellular pool of Cr in skeletal and cardiac muscles in rats. The hormone can regulate these processes in distinct ways in different muscle types. (AU) | |