Influência do hormônio tireoideano na atividade do gonadotrofo.

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Author(s):	Renata Marino Romano Total Authors: 1
Document type:	Doctoral Thesis
Press:	São Paulo.
Institution:	Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI)
Defense date:	2011-08-15
Examining board members:	Maria Tereza Nunes; Maria Christina Werneck de Avellar; Ubiratan Fabres Machado; Célia Regina Nogueira; Claudio Alvarenga de Oliveira
Advisor:	Maria Tereza Nunes
Abstract
Reproductive disorders occur in hypo and hyperthyroidism, but little is known about the molecular basis of these alterations. The effect of administration of triiodothyronine (T3) on the activity of gonadotropes in thyroidectomyzed male Wistar rats was evaluated. Hypothyroidism caused increased on TSH and LH serum concentrations, increased of mRNA content and decreased in protein content of LH and FSH, reduction in the length of poli(A) tail of LH, reduction in testosterone and FSH serum concentrations, reduction in the expression of LH receptor, increased in the expression of androgen receptors in the testis and epididymis. T3 treatment caused reduction on mRNA and increased on mRNA of LH and FSH, increased serum FSH, increased the expression of LH receptor, and reduction of the expression of androgen receptors in the testis and epididymis. These results suggest that T3 modulates the function of gonadotrope and the expression of the receptors in target-tissues. (AU)