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| Author(s): |
Arnaldo Henrique de Souza
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) |
| Defense date: | 2011-10-24 |
| Examining board members: |
Fabio Bessa Lima;
Miriam Helena Fonseca Alaniz;
Marilia Cerqueira Leite Seelaender
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| Advisor: | Fabio Bessa Lima |
| Abstract | |
The objective of this study was to determine whether the metabolism of white adipose tissue (TAB) of total reversibility trained animals suffer in a long period of detraining. Wistar rats were divided into three groups: trained (T), untrained (D) and sedentary (S). The T group showed a reduction in mass and diameter of cells from SC, PE and RP fat pads, although the cellularity showed similar results in the three groups. We found in group D, a part of insulin resistance, represented by the increase in plasma insulin and the HOMA index, compared to other groups (S and T). Uptake of 2-deoxy-D-glucose, D group had a lower response to insulin than in group S. Regarding the capacity to incorporate glucose into TAG, the group had a lower response when T cells were stimulated with insulin. Group D had an increase in the incorporation of glucose into fatty acids (FA) compared to T. On the other hand, the activity of enzymes lipogências not differ between groups. In short, these data suggest that the lipogenic capacity in untrained TAB undergoes reversible. In addition, a framework for peripheral insulin resistance is observed with the discontinuation of physical training. Our findings rule out the hypothesis that there would be an increase in fat mass after 8 weeks of detraining compared to sedentary status. (AU) | |
| FAPESP's process: | 09/11780-1 - EFFECTS ON THE PHYSICAL DETRAINING MUFF CALORIC INTAKE, BODY WEIGHT, IN THE METABOLISM OF ADIPOCYTE AND TRANSCRIPTION FACTORS RESPONSIBLE FOR ADIPOGENESIS IN MALE WISTAR |
| Grantee: | Arnaldo Henrique de Souza |
| Support Opportunities: | Scholarships in Brazil - Master |