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| Author(s): |
Pedro Valadão Carelli
Total Authors: 1
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| Document type: | Doctoral Thesis |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Física (IF/SBI) |
| Defense date: | 2008-05-29 |
| Examining board members: |
Reynaldo Daniel Pinto;
Joaquim Procopio de Araujo Filho;
Mario Jose de Oliveira;
Rita Maria Zorzenon dos Santos;
Antonio Carlos Roque da Silva Filho
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| Advisor: | Reynaldo Daniel Pinto |
| Abstract | |
We developed a mathematical model of the electrical activity of a motor neuron from the stomatogastric ganglion of crustaceans. It was inspired on a previous existing deterministic model which is considered as electrophysiologically plausible in the recent literature. However, this deterministic model were not able to reproduce the irregular bursting behavior found in those biological neurons when isolated from the neural circuit. Our model, based on the microscopic stochastic behavior of the membrane ion channels, successfully reproduced the intrinsic irregular properties that were missing in the original deterministic model. To allow the real time performing of the stochastic model simulations we have to deal with some simplifications and to implement several optimizations that are also describe in detail. The real time version of our stochastic model was implemented in a dynamic clamp protocol to interface the computational model to real neurons. Finally, we applied the implemented versions of real time simulation and interfacing protocols to replace some biological bursting neurons of the stomatogastric ganglion. These hibrid neural networks were used to study how the information (diferent patterns of interspike intervals) is transmitted between biological and two types of artificial neurons: deterministic and stochastic. (AU) | |
| FAPESP's process: | 03/04869-0 - Desenvolvimento de um modelo estocastico in silico da atividade eletrica de neuronios motores e sua interacao em tempo real com neuronios biologicos. |
| Grantee: | Pedro Valadão Carelli |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |