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Generalized linear models for repeated measures regression analysis

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Author(s):
Maria Kelly Venezuela
Total Authors: 1
Document type: Master's Dissertation
Press: São Paulo.
Institution: Universidade de São Paulo (USP). Instituto de Matemática e Estatística (IME/SBI)
Defense date:
Examining board members:
Denise Aparecida Botter; Rinaldo Artes; Antonieta D'Alcantara de Queiroz Peres
Advisor: Denise Aparecida Botter
Abstract

In this work, we consider the generalized estimation equations developed by Liang and Zeger (1986) focusing the theory of estimating functions presented by Godambe (1991). These estimation equations are an extension of generalized linear models (GLMs) to the analysis of repeated measurements. We present an iterative procedure to estimate the regression parameters as well as hypothesis testing of these parameters. For the residual analysis, we generalize to repeated measurements some diagnostic methods available for GLMs. The half-normal probability plot with a simulated envelope is useful for diagnosing model inadequacy and detecting outliers. To obtain this plot, we consider an algorithm for generating a set of nonnegatively correlated variables having a specified correlation structure. Finally, the theory is applied to real data sets. (AU)