Analysis of association applied to the genetic diseases mapping.

Author(s)

Maria Jacqueline Batista

• Document type: Master's Dissertation
• Press: São Paulo.
• Institution: Universidade de São Paulo (USP). Instituto de Matemática e Estatística (IME/SBI)
• Defense date: 2006-03-03

Examining board members

Julia Maria Pavan Soler; Dalton Francisco de Andrade; Cibele Queiroz da Silva

• Advisor: Julia Maria Pavan Soler

Abstract

The genetic mapping and functional genetics have great importance in the genomics research. In order to conduct these researches the study of the association between genetic risk factors and disease has been becoming an important role in the literature. In this work we consider the association analyses applied to the genetic diseases mapping, charactering different possibilities of experimental designs and the use of statistical models to analyze data sets. The statistical concepts, as the kind of experimental design, the inclusion of familiar records or not, as well as the choice of the statistical analyze method, which are very important to the evaluation of the power of the tests obtained and to their applicability in the genetic mapping, are also discussed. Furthermore, we consider the association analysis at person level and chromosome data set. Finally, the latter concepts are applied to a real data set, provided by the Molecular Genetic and Cardiology Laboratory of InCor/USP, in order to illustrate the theoretical problem treated in this work and to motive the use of the involved statistical methodologies. (AU)