Idiopathic interstitial pneumonias : of the pathogenesis and remodeling to anatomic-physician-radiological determinatives of prognostic and survival with emphasis to the vascular component

Author(s)

Edwin Roger Parra Cuentas

• Document type: Doctoral Thesis
• Press: São Paulo.
• Institution: Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD)
• Defense date: 2006-05-04

Examining board members

Vera Luiza Capelozzi; Maria Irma Seixas Duarte; Jose Antonio Baddini Martinez; Mirian Nacagami Sotto; Roberto Stirbulov

• Advisor: Vera Luiza Capelozzi

Abstract

Studied for morphology, morphometry and immunohischemistry the vascular (adhesion molecules), epithelial (adhesion molecules) and interstitial (collagen V and immune cells) remodeling in the three major types of idiopathic interstitial pneumonias: in 62 cases of IPF, 22 cases of NSIP, and 25 cases of AIP. The impact of these alterations was evaluated in the function tests, survival and prognostic. We demonstrated that the active and fibroelastotic vascular remodeling is directly proportional to the degree of parenchymal activity, mainly in the UIP. Collagen V, mapping of the immune cells, increase of the endothelial and epithelial activity had possibly impact in the distinguishing specter and in pathogenesis of the three interstitial pneumonias studied. The cellular immune reply in the UIP it had impact in survival of the patients (AU)