Study of transcriptional profile in operationally tolerant patients
mRNAs, miRNAs and Regulatory Molecules Expression profile in the Immune Response i...
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Study of the immunologic molecular profile in operational tolerance kidney transplanted individuals
Full text
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| Author(s): |
Pedro Manoel Mendes de Moraes Vieira
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) |
| Defense date: | 2009-05-08 |
| Examining board members: |
Veronica Porto Carreiro de Vasconcellos Coelho;
David Saitovitch;
Maria Notomi Sato
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| Advisor: | Veronica Porto Carreiro de Vasconcellos Coelho |
| Abstract | |
standard immunosuppression, lead us to suggest that these cells may be affected by immunosuppression. Moreover, the higher numbers of CD4+CD25+Foxp3+ T cells observed in TO and BI individuals suggest that these cells may have an important role in the induction/maintenance of these two homeostatic states of minimal, or of no aggression to the graft. Furthermore, the higher mRNA expression of GATA-3, in the TO group, suggests that a Th2 deviation may also be relevant to the maintenance of operational tolerance. Our results allowed us to interpret that the state of operational tolerance has systemic repercussion, and that the molecules studied in our work may be relevant to the process of homeostasis in the context of human kidney transplantation. (AU) | |
| FAPESP's process: | 06/53133-4 - Study of transcriptional profile in operationally tolerant patients |
| Grantee: | Pedro Manoel Mendes de Moraes Vieira |
| Support Opportunities: | Scholarships in Brazil - Master |