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| Author(s): |
Giselle de Angelo Souza Leite
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | Ribeirão Preto. |
| Institution: | Universidade de São Paulo (USP). Faculdade de Odontologia de Ribeirão Preto (PCARP/BC) |
| Defense date: | 2009-09-18 |
| Examining board members: |
Raquel Fernanda Gerlach;
Maria Cristina Borsatto;
Frederico Barbosa de Sousa
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| Advisor: | Raquel Fernanda Gerlach |
| Abstract | |
Co-exposure to lead and fluoride may alter the degree of dental fluorosis, since both accumulate in calcified tissues. Wistar rats were allocated in four groups: control, and 3 groups that received water containing 100 ppm of fluoride (F), 30 ppm of lead (Pb), or 100 ppm of F and 30 ppm of Pb (F+Pb) since gestational age. Enamel analysis and F determinations in enamel, dentine, and bone were performed in 81-day-old animals. Incisor defects were scored using an index that discriminated surface lesions as bands, islets, and pits. There were no differences in the F concentration in calcified tissues between the F and F+Pb groups. The control and the Pb groups presented normal enamel. The F+Pb group presented more severe enamel defects compared with the F group (P<0.001). This study shows that Pb exacerbates dental fluorosis in rodents, suggesting that co-exposure to Pb may explain differences in fluorosis prevalence. (AU) | |