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| Author(s): |
Rafael Assumpção Larocca
Total Authors: 1
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| Document type: | Doctoral Thesis |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) |
| Defense date: | 2009-10-19 |
| Examining board members: |
Niels Olsen Saraiva Câmara;
Jose Alexandre Marzagao Barbuto;
Alexandre Salgado Basso;
Valquiria Bueno;
Marilda Mazzali
|
| Advisor: | Niels Olsen Saraiva Câmara |
| Field of knowledge: | Biological Sciences - Immunology |
| Indexed in: | Banco de Dados Bibliográficos da USP-DEDALUS; Biblioteca Digital de Teses e Dissertações - USP |
| Location: | Universidade de São Paulo. Biblioteca do Instituto de Ciências Biomédicas; T-ICB BMI QW504 2009; L326mr |
| Abstract | |
The identification and characterization de regulatory T cells that can control immune responsiveness to alloantigens opened up opportunities for new therapies in transplantation. After exposure to alloantigens in vivo, antigen-specific immunoregulatory activity is enriched in a population of CD4+ T cells that express high levels of CD25 and Foxp3. Adipose tissue contains one type of mesenchymal stem cells (ADSC) with capacity of suppressing immune response. In this work we propose the correlation of the ADSC cells in ameliorating skin graft survival, and if is associated with Foxp3 expression. Graft survival was enhanced in animals that received ASCs from the donor. Interesting, in the animals treated with ASCs from CBA presented a higher expression of Foxp3+ cells in the lymph-nodes. In treated mice Foxp3 expression was increased and IL-17 were increased in allogeneic group, suggesting a potent inflammatory response inside the graft. So far, these data suggest the ADSCs increase TReg population cells, inhibit IL-17 expression and prolonging skin graft survival. (AU) | |
| FAPESP's process: | 06/55326-4 - TCD4+regulatory cell induction by mesenchymal stem cells |
| Grantee: | Rafael Assumpção Larocca |
| Support Opportunities: | Scholarships in Brazil - Doctorate |