Rhenium and technetium chelate-complexes of potential medicinal application

Author(s)

André Gustavo de Araujo Fernandes

• Document type: Doctoral Thesis
• Press: São Carlos.
• Institution: Universidade de São Paulo (USP). Instituto de Química de São Carlos (IQSC/BT)
• Defense date: 2012-05-11

Examining board members

Victor Marcelo Deflon; Ana Maria da Costa Ferreira; Fabio Luiz Navarro Marques

• Advisor: Victor Marcelo Deflon

Abstract

This work evaluated the coordination mode of pyridinones, dithiocarbazates and N-(N\'\',N\'\'-Diethylaminothiocarbonyl)-N\'-(2-hydroxyphenyl)benzamidine, to the metal centers Re (V) and Tc (V). For this purpose, the compounds trichlorobis(triphenylphosphine)oxorhenium(V), [ReOCl3(PPh3)2]43, tribromobis(triphenylphosphine)oxorhenium(V), [ReOBr3(PPh3)2]43, and tetra-n-butyl)ammonium tetrachlorooxorhenate(V), (NBu4)[ReOCl4]44, were synthesized and used as starting materials. The precursor tetra-n-butylammonium tetrachlorooxotechnetate(V), (NBu4)[TcOCl4] was synthesized and released by the Prof. Dr. Ulrich Abram\'s group, at the Freie Universität Berlin, during my research time in Germany. <br /> The complexes were characterized by infrared absorption spectroscopy, elemental analyses (CHNS), mass spectrometry with electrospray ionization (MSESI), nuclear magnetic resonance spectroscopy (31P, 1H and, in one case, also 13C) and had their crystalline and molecular structures, when possible, properties determined by X-ray diffraction on single crystals. Due to its radioactive element, the 99Tc values were determined by standard liquid scintillation counting. <br /> Since the beginning of this work were synthesized and characterized by various techniques 14 new rhenium and 1 technetium complexes, all of then unknown in the literature. All the complexes presented here were obtained in good or excellent yields. Six new dithiocarbazates were obtained and characterized, of which 5 are unknown. (AU)

• FAPESP's process: 07/02595-0 - Synthesis and characterization of rhenium and technetium chelate-complexes of potential medicinal application
• Grantee: André Gustavo de Araujo Fernandes
• Support Opportunities: Scholarships in Brazil - Doctorate