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| Author(s): |
Rafael Peres
Total Authors: 1
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| Document type: | Doctoral Thesis |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) |
| Defense date: | 2013-04-18 |
| Examining board members: |
Jose Cipolla Neto;
Eduardo Gorab;
Carlos Arturo Navas Iannini;
Antonio Carlos Marques;
André Carrara Morandini
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| Advisor: | Jose Cipolla Neto; Antonio Carlos Marques |
| Abstract | |
The adipose tissue is critical to puberty. Leptin exerts a permissive role to hypothalamic-hypophysial-gonadal maturation and, thereby, adipose tissue is necessary to pubertal development. Despite its importance to puberty, little is known about the process of adipose tissue formation during this period of life. Researches have described insulin resistance at pubertal period in humans. The adipose tissue importance to puberty added to pubertal insulin resistance described in humans lead us to investigate how the adipose tissue responds to insulin at this period since it is essential at this time. We assessed two distinct fat pads: the subcutaneous fat pad and the epididymal one. At the puberty, despite the temporary glucose intolerance and the constraint for glucose utilization by insulin-dependent tissues, the adipose tissue had normal insulin responsiveness plus an improved capacity to synthesize lipids from glucose which led us to hypothesize that glucose could have been deviated towards the adipose tissue. (AU) | |
| FAPESP's process: | 09/01128-5 - Melatonin synthesis pathway in invertebrates: presence and functional aspects |
| Grantee: | Rafael Peres |
| Support Opportunities: | Scholarships in Brazil - Doctorate |