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| Author(s): |
Carla Rocha dos Santos
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | São Paulo. |
| Institution: | Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) |
| Defense date: | 2013-11-25 |
| Examining board members: |
Lisete Compagno Michelini;
Sandra Lia do Amaral Cardoso;
Kátia de Angelis Lobo D'Avila
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| Advisor: | Lisete Compagno Michelini |
| Abstract | |
There is evidence aerobic training (T) determines plastic and functional changes in the suprabulbar modulatory loop of the cardiovascular autonomic control, many of them mediated by arterial baroreceptors. The present study aim to investigate the effects of sinoaortic denervation associated or not to T on noradrenergics, oxitocinergics, vasopressinergics neurons expression, as temporal effects induced by T. It was possible find augment on dopamine beta-hydroxilase and oxytocin expression, without changes on vasopressin expression, and that neuropeptidergic changes preceding appearance of beneficial training-induced, as well the increases baroreflex sensitivity and resting bradycardia. Data also indicate that sinoaortic denervation blocks all of these effects training-induced, decreases of dopamine beta-hidroxylase, vasopressin and oxytocin on the PVN. Therefore, those data suggests that noradrenergic afferents driven by barorreceptors are essencial to trigger beneficial training-induced cardiovascular adjustments. (AU) | |
| FAPESP's process: | 11/15676-4 - Expression/activity of ascending noradrenergic pathways to the hypothalamus: Effects of sinoaortic denervation and aerobic training. |
| Grantee: | Carla Rocha dos Santos |
| Support Opportunities: | Scholarships in Brazil - Master |