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P1 cortical auditory evoked potential in the first months of cochlear implant use in auditory neuropathy spectrum disorder

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Author(s):
Leticia Cristina Vicente
Total Authors: 1
Document type: Master's Dissertation
Press: Bauru.
Institution: Universidade de São Paulo (USP). Faculdade de Odontologia de Bauru (FOB/SDB)
Defense date:
Examining board members:
Katia de Freitas Alvarenga; Orozimbo Alves Costa Filho; Ana Claudia Figueiredo Frizzo
Advisor: Katia de Freitas Alvarenga
Abstract

Cochlear implants have been considered a rehabilitation option in patients with auditory neuropathy spectrum disorder. However, their indication is relatively recent, thus, few studies have investigated cortical development in these patients. So far, no longitudinal study has characterized the development of the central auditory system, following cochlear implant activation. This study aimed at characterizing P1 cortical auditory evoked potential in the first months of cochlear implant use, in children presented with auditory neuropathy spectrum disorder. Eight children diagnosed with auditory neuropathy spectrum disorder, with severe or profound pre-lingual hearing loss, users of cochlear implant, participated in this study. The cortical auditory evoked potential research was performed with the /da/ speech stimulus presented in free field, in three assessment sessions: at electrodes activation, at three and at six months, following cochlear implant activation. The recordings obtained were analyzed by the researcher and by an experienced electrophysiologist, so as to verify the agreement of the analyses. There was 100% agreement (Kappa=1) between the referees, as to the occurrence of component P1, with an excellent interclass correlation coefficient for latency and amplitude values. Regarding morphology, P1 was characterized as a robust positive peak in the first assessment session, being recorded in 71.43% of the sample, in the first session, in 87.50%, in the second, and in 85.71%, in the third. In patients in whom it was possible to observe P1 in all assessment sessions, a latency reduction was observed, considering the first and last time of evaluation, nevertheless, the results were shown to be heterogeneous among the children assessed. Thus, in the P1 cortical auditory evoked potential research, it was not possible to determine a behavior pattern of this component in children presented with auditory neuropathy spectrum disorder, in the first six months of cochlear implant use. (AU)

FAPESP's process: 12/16621-1 - Cortical auditory evoked potential in the first months of cochlear implant use in the Auditory Neuropathy Spectrum Disorder.
Grantee:Leticia Cristina Vicente
Support Opportunities: Scholarships in Brazil - Master