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DETECTION, QUANTIFICATION AND COMPOSITION FOR CYTOCHROME C RELEASED FROM MITOCHONDRIA
| Office | WIPO |
| Document type: | Patent |
| Inventor(s): | Cláudia Barbosa Ladeira De Campos; Ricardo G. Cosso; Roger F. Castilho; Hagai Rottenberg; Aníbal E. Vercesi |
| Applicant: | Aníbal E. Vercesi; Cláudia Barbosa Ladeira de Campos; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Hagai Rottenberg; Ricardo G. Cosso; Roger F. Castilho |
| Year: | 2004 |
| Application Number: | PCT/BR2004/000022 |
| IPC: | G01N 33/533 G01N 33/535 G01N 33/68 G01N 33/92 |
Abstract
A method to quantify a cytochrome c released from mitochondria during cellul death comprising selective permeabilization of the plasma membrane and cytochrome c immunodetection is described. The present invention also regards a composition to detect cytochrome c released from mitochondria, a kit for detection of cytochrome c released from mitochondria, as well as the use of a composition for detection of cytochrome c released from mitochondria.
| FAPESP's process: | 02/09210-3 - A new method to quantify mitochondrial cytochrome c release during cell death: immunodetection of cytochrome c following selective permeabilization of the plasma membrane |
| Grantee: | Aníbal Eugênio Vercesi |
| Principal Investigator: | Aníbal Eugênio Vercesi |
| Institution: | Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas (FCM) |
| Support Opportunities: | Research Grants - Support for Intellectual Property Rights and Licensing (PAPI/Nuplitec) |