IMMUNOGENIC COMPLEX FORMED BY VACCINAL ANTIGENS ENCAPSULATED BY NANOSTRUCTURED MESOPOROUS SILICA
| Document type: | Patente |
| Inventor(s): | Ogari de Castro Pacheco; Osvaldo Augusto Brazil Esteves Sant'Anna; Lucildes Pita Mercuri; Jivaldo do Rosário Matos; Marcia Carvalho de Abreu Fantini |
| Applicant: | Cristália Produtos Químicos Farmacêuticos Ltda ; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) |
| Deposit date: | September 2006, 12 |
| INPI register: | |
| IPC: | A61K 39/00 A61K 39/39 |
The present invention relates to a product named 'immunogenic complex', which comprises an adjuvant characterized by solid particles of highly ordered nanostructured mesoporous silica, preferably, the silica SBA-15, and vaccinal antigens from distinct nature, encapsulated in this kind of adjuvant. The immunogenic complex of the present invention allows the presentation of the antigens that compose it to lymphocytes in a safe, gradual and sustained way, which leads to a more efficient immunological memory, increases the immunogenicity of the antigen and improves the production of antibodies. It ensures an efficient immunological protection with lower amounts of antigens and/or less repetition of vaccinal doses. In addition, the characteristics of the immunogenic complex of the present invention promote effective immunity induction, homogeneous in 'high and low responder' individuals.
| Grantee: | Luciana Vieira Carvalho |
| Principal Investigator: | Osvaldo Augusto Brazil Esteves Sant'Anna |
| Institution: | Secretaria da Saúde (São Paulo - Estado). Instituto Butantan |
| Support Opportunities: | Scholarships in Brazil - Master |