MODIFIED BACTERIAL STRAIN AND USE THEREOF
| Document type: | Patente |
| Inventor(s): | Angelo Berchieri Junior |
| Applicant: | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) ; Universidade Estadual Paulista (UNESP) |
| Deposit date: | December 2010, 22 |
| INPI register: | |
| IPC: | C12Q 1/68 C12N 15/66 A61K 39/112 C12R 1/42 |
The present invention relates to a mutant of Salmonella gallinarum that is defective in the CobS and CbiA (SGCobSCbiA) genes, which are associated with the production of cobalamin by the bacterium in anaerobic conditions, for use as vaccines. The present invention also relates to the use of said mutant Salmonella gallinarum strain for inducing protection in birds against infection by the homologous natural strain and Salmonella enteritidis strain by means of a vaccine. (FR)La présente invention concerne un mutant de Salmonella gallinarum défectif dans les gènes CobS et CbiA (SGCobSCbiA), qui sont associés à la production de cobalamine par la bactérie dans des conditions anaérobies, en vue d'une utilisation comme vaccins. La présente invention concerne également l'utilisation de ladite souche mutante de Salmonella gallinarum pour induire chez des oiseaux une protection contre l'infection par la souche homologue naturelle et la souche de Salmonella enteritidis au moyen d'un vaccin.
| FAPESP's process: | 08/01386-1 - Immunization of poultry by an attenuated strain of Salmonella Gallinarum |
| Grantee: | Angelo Berchieri Junior |
| Principal Investigator: | Angelo Berchieri Junior |
| Institution: | Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Faculdade de Ciências Agrárias e Veterinárias (FCAV) |
| Support Opportunities: | Research Grants - Support for Intellectual Property Rights and Licensing (PAPI/Nuplitec) |