ISOLATION AND PURIFICATION PROCEDURE OF VASOPEPTIDASE PEPTIDE INHIBITORS
| Office | USPTO |
| Document type: | Patent |
| Inventor(s): | Antônio Carlos Martins De Camargo; Fernanda Calheta Vieira Portaro; Alessandra Ferragini Murback; Danielle Alves Ianzer; Sandra Helena Poliselli Farsky; Mario Sergio Palma; Mirian Akemi Furuie Hayashi |
| Applicant: | Antonio Carlos Martins de Camargo; Biolab Sanus Farmacêutica Ltda; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) |
| Year: | 2002 |
| Application Number: | US 10/471,931 |
| IPC: | A61K 038/43 C12N 009/99 C12P 021/06 |
The present invention patent refers to the isolation and purification of peptides secreted by serpent venom glands, specifically Bothrops jararaca; to the peptide thus obtained, as well as to the production procedures by genetic engineering techniques in procaryotic and eukaryotic systems; to the engineered peptide thus obtained; to the production of said peptide by chemical synthesis, as well as to the peptide resulting from this chemical processing. It also refers to the utilization of said peptides, obtained by different procedures, in distinct pharmaceutical compositions, and introduced into the organism by a variety of means, in order for them to act as inhibitors of vasopeptidases, and consequently reduce systemic arterial blood pressure, and show local vasodilating action.
| Grantee: | Mirian Akemi Furuie Hayashi |
| Principal Investigator: | Antonio Carlos Martins de Camargo |
| Institution: | Secretaria da Saúde (São Paulo - Estado). Instituto Butantan |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |