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METHOD OF IDENTIFICATION AND QUANTIFICATION OF PROTEINS, ISOFORMS OF THE ANGIOTENSIN I CONVERTING ENZYME
| Office | USPTO |
| Document type: | Patent |
| Inventor(s): | Dulce Elena Casarini; Odair Marson; Frida Liane Plavnik; José Eduardo Krieger |
| Applicant: | Universidade Federal de São Paulo (Unifesp) |
| Year: | 2003 |
| Application Number: | US 10/540,193 |
| IPC: | G01N 33/53 |
Abstract
The present invention relates to a method of identification and quantification of proteins, isoforms of angiotensin I converting enzymes (ACE), 190-kDa, specially of 90kDa in tissues, cells and biological fluids, specially in urine, genetic marker and prognostic agent of hypertension and primary or secondary renal lesion and kit for using in the diagnosis, risk stratification and therapeutical decision in arterial hypertension. One the aims of the present invention is to check the potential of the 90 kDa isoform as a hypertension genetic marker isoform and as a prognostic for hypertension.
| FAPESP's process: | 02/13290-2 - Angiotensin I: converting enzyme isoform (90 kDa), potential genetic marker of hypertension: processing, molecular and functional characterization, and genetic segregation |
| Grantee: | Dulce Elena Casarini |
| Principal Investigator: | Dulce Elena Casarini |
| Institution: | Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) |
| Support Opportunities: | Research Projects - Thematic Grants |
| Grantee: | Dulce Elena Casarini |
| Principal Investigator: | Dulce Elena Casarini |
| Institution: | Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) |
| Support Opportunities: | Research Grants - Support for Intellectual Property Rights and Licensing (PAPI/Nuplitec) |