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CYCLOPALLADATED COMPOUNDS COMPRISING BIS-DIPHENYLPHOSPHINE-FERROCENE LIGANDS, AND THEIR USE IN TREATING DISEASES
| Office | CIPO |
| Document type: | Patent |
| Inventor(s): | Antonio Carlos Fávero Caires; Claudia Bincoletto Trindade; Ivarne Luis Dos Santos Tersariol |
| Applicant: | Antonio Carlos Fávero Caires; Claudia Bincoletto Trindade; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Ivarne Luis Dos Santos Tersariol |
| Year: | 2003 |
| Application Number: | CA 2496681 |
| IPC: | A61K 31/28 A61K 31/555 C07F 15/00 C07F 17/02 |
Abstract
The invention relates to cyclopalladated compounds containing bis diphenylphosphine-ferrocene ligands and their analogues which are active inhibitors of proteins and enzymes, for example, those of the serine peptidase, cysteine-protease, metalo-protease and endopeptidase families, involved in the development and metastases of malignant tumors, e.g. of the thyroid. An exemplary compound is shown in the figure. The compounds are able te modulate the immunological system due to their action on the enzymes and their interaction with DNA molecules.
| Grantee: | Antonio Carlos Fávero Caires |
| Principal Investigator: | Antonio Carlos Fávero Caires |
| Institution: | Universidade de Mogi das Cruzes (UMC). Centro de Ciências Exatas e Tecnologia |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| Grantee: | Andrea Licia de Almeida Oliveira |
| Principal Investigator: | Andrea Licia de Almeida Oliveira |
| Institution: | Universidade de Mogi das Cruzes (UMC). Campus da Sede Mogi das Cruzes |
| Support Opportunities: | Research Grants - Support for Intellectual Property Rights and Licensing (PAPI/Nuplitec) |