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ACYL-HYDRAZONE AND OXADIAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND USES THEREOF
| Office | CIPO |
| Document type: | Patent |
| Inventor(s): | Ricardo José Nunes; Alessandra Mascarello; Taisa Regina Stumpf; Paulo César Leal; José Andres Yunes; Carolina Pereira De Souza Melo; Rafael Renatino Canevarolo; Louise Domeneghini Chiaradia; Rosendo A. Yunes; Ângelo Bruneli Albertoni Laranjeira |
| Applicant: | Centro Infantil de Investigações Hematológicas Dr Domingos A Boldrini (CIB); Universidade Federal de Santa Catarina (UFSC) |
| Year: | 2012 |
| Application Number: | CA 2869807 |
| IPC: | A61K 31/166 A61K 31/381 A61K 31/4164 A61P 35/02 C07C 251/86 C07D 233/54 C07D 271/107 C07D 333/02 |
Abstract
The present invention relates to a compound of formula l (see formula I) wherein the Ring B represents a substituent selected from the group consistingof phenyl, 4-Br-phenyl, 4-NO2-phenyl; 3-OCH3-phenyl; 1-naphthyl; 2-naphthyl; 4-Cl-phenyl; 3-OCH2CH3-4-OH-phenyl; and 2-OH-4-Br-phenyl. For example, such a compound can be used for treating cancer.
| FAPESP's process: | 09/04167-1 - Metabolomics of methotrexate resistance in acute lymphoblastic leukemia |
| Grantee: | Rafael Renatino Canevarolo |
| Principal Investigator: | José Andrés Yunes |
| Institution: | Centro Infantil de Investigações Hematológicas Dr Domingos A Boldrini (CIB) |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 12/11952-0 - Methotrexate resistance is directly associated with glutathione concentration in acute lymphoblastic leukemia cell lines |
| Grantee: | Rafael Renatino Canevarolo |
| Principal Investigator: | José Andrés Yunes |
| Institution: | Centro Infantil de Investigações Hematológicas Dr Domingos A Boldrini (CIB) |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 08/02106-2 - IGFBP7 role in chemotherapy resistance of Pediatric Acute Lymphoblastic Leukemia |
| Grantee: | Angelo Brunelli Albertoni Laranjeira |
| Principal Investigator: | José Andrés Yunes |
| Institution: | Centro Infantil de Investigações Hematológicas Dr Domingos A Boldrini (CIB) |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 12/03039-2 - IGFBP7 and insulin/IGFs in Childhood Acute Lymphoblastic Leukemia chemoresistance |
| Grantee: | Angelo Brunelli Albertoni Laranjeira |
| Principal Investigator: | José Andrés Yunes |
| Institution: | Centro Infantil de Investigações Hematológicas Dr Domingos A Boldrini (CIB) |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 14/08247-8 - Preclinical studies of novel inhibitors of DNA methyltransferase in acute leukemia |
| Grantee: | Nathalia Moreno Cury |
| Principal Investigator: | José Andrés Yunes |
| Institution: | Centro Infantil de Investigações Hematológicas Dr Domingos A Boldrini (CIB) |
| Support Opportunities: | Scholarships in Brazil - Doctorate |