IMMUNOGENIC COMPLEX FORMED BY VACCINAL ANTIGENS ENCAPSULATED BY NANOSTRUCTURED MESOPOROUS SILICA
| Office | CNIPA |
| Document type: | Patent |
| Inventor(s): | Ogari De Castro Pacheco; Osvaldo Augusto Brazil Esteves Sant'Anna; Lucildes Pita Mercuri; Jivaldo Do Rosário Matos; Marcia Carvalho De Abreu Fantini |
| Applicant: | Cristália Produtos Químicos Farmacêuticos Ltda; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) |
| Year: | 2006 |
| Application Number: | CN 200680038399 |
| IPC: | A61K 39/00 A61K 39/39 |
The present invention relates to a product named "immunogenic complex" comprising an adjuvant and encapsulated in solid particles of mesoporous silica characterized by a highly ordered nanostructure, preferably SBA-15 silica. Vaccine antigens of different nature in adjuvants. The immunogenic complex of the present invention is capable of presenting its constituent antigens to lymphocytes in a safe, stepwise and prolonged manner, which leads to more efficient immune memory, increased immunogenicity of antigens and improved antibody production. It ensures that effective immune protection is repeatedly achieved using lower amounts of antigen and/or fewer vaccine doses. Furthermore, the characteristics of the immunogenic complexes of the present invention promote efficient immune induction, homogeneous among "high and low responder" individuals
| Grantee: | Luciana Vieira Carvalho |
| Principal Investigator: | Osvaldo Augusto Brazil Esteves Sant'Anna |
| Institution: | Secretaria da Saúde (São Paulo - Estado). Instituto Butantan |
| Support Opportunities: | Scholarships in Brazil - Master |