COLLOIDAL NANOSCALE CARRIERS FOR ACTIVE HYDROPHILIC SUBSTANCES AND METHOD FOR PRODUCING SAME

The present invention “Colloidal nanoscale carrier for hydrophilic active substances and process for its production” relates to the field of medical preparations, dentistry preparations or hygiene preparations and has an affinity for non-hydrophilic phases and components. Formed from a hydrophilic polymer containing a hydrophilic active agent that is coated with a surface active agent to form an inverse emulsion that allows for the incorporation and controlled delivery of the hydrophilic active agent, protecting it from degradation processes; Improving the compatibility of the final product with other ingredients of the formulation, increasing the availability and / or bioavailability of the active substance in the target medium (improving the permeation process in the biological material and the active substance) And the like, and imparting properties such as controlled release of the active substance. Nanoscale carriers obtained by this method are called colloidal nanoscale carriers (NC), and are very useful for pharmaceuticals (including dermatological drugs), cosmetics, personal hygiene products, veterinary medicines, agricultural chemicals and fertilizers, food industries, etc. It can be used in various fields. The present invention relates to an effective nanoscale consisting of a nanoscale carrier formed by a polymer emulsified in a non-aqueous solvent in the presence of a surfactant having an affinity for two phases (dispersion medium and encapsulant). A kinetically stable system with a scale structure is proposed. This system is obtained by nanoemulsification of an aqueous phase of a hydrophilic polymer that is emulsified in a non-hydrophilic (lipophilic or lipophilic) phase containing a surfactant, producing a reverse nanoscale emulsion and polymer nanoparticles It is characterized by the implementation of two concepts including: This formulation provides a polymer excipient with a nanoscale structure for delivering hydrophilic molecules suspended in a non-hydrophilic phase to control the nanoscale particle size and use process parameters It has a new technical effect that makes it possible to adjust the stability of the colloid.