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ACYL-HYDRAZONE AND OXADIAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND USES THEREOF
| Office | JPO |
| Document type: | Patent |
| Inventor(s): | Ricardo José Nunes; Alessandra Mascarello; Rosendo Augusto Yunes; Taisa Regina Stumpf; Paulo Cesar Leal; José Andres Yunes; Carolina Pereira De Souza Melo; Rafael Renatino Canevarolo; Louise Domeneghini Chiaradia; André Bortolini Silveira; Anqelo Brunelli Albertoni Laranjeira |
| Applicant: | Alessandra Mascarello; André Bortolini Silveira; Carolina Pereira de Souza Melo; José Andres Yunes; Louise Domeneghini Chiaradia; Paulo Cesar Leal; Rafael Renatino Canevarolo; Ricardo José Nunes; Rosendo Augusto Yunes; Taisa Regina Stumpf; Universidade Federal de Santa Catarina (UFSC) |
| Year: | 2012 |
| Application Number: | JP2015504432A |
| IPC: | C07D 333/22 |
Abstract
The present invention relates to acyl-hydrazones derived from 3,4,5-trimethoxyphenylhydrazide for treating diseases associated with cell proliferation (eg, leukemia, tumors, inflammation and other proliferative diseases). The purpose is to provide. The present invention relates to acyl-hydrazone compounds, particularly for cell proliferation such as 3,4,5-trimethoxyphenyl-hydrazide derivatives, and their oxadiazole analogs and other similar compounds, and leukemias. These pharmaceutical uses for treating various related diseases such as acute lymphoblastic leukemia (ALL), tumors and inflammation are provided.
| FAPESP's process: | 09/04167-1 - Metabolomics of methotrexate resistance in acute lymphoblastic leukemia |
| Grantee: | Rafael Renatino Canevarolo |
| Principal Investigator: | José Andrés Yunes |
| Institution: | Centro Infantil de Investigações Hematológicas Dr Domingos A Boldrini (CIB) |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 12/11952-0 - Methotrexate resistance is directly associated with glutathione concentration in acute lymphoblastic leukemia cell lines |
| Grantee: | Rafael Renatino Canevarolo |
| Principal Investigator: | José Andrés Yunes |
| Institution: | Centro Infantil de Investigações Hematológicas Dr Domingos A Boldrini (CIB) |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 08/02106-2 - IGFBP7 role in chemotherapy resistance of Pediatric Acute Lymphoblastic Leukemia |
| Grantee: | Angelo Brunelli Albertoni Laranjeira |
| Principal Investigator: | José Andrés Yunes |
| Institution: | Centro Infantil de Investigações Hematológicas Dr Domingos A Boldrini (CIB) |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 12/03039-2 - IGFBP7 and insulin/IGFs in Childhood Acute Lymphoblastic Leukemia chemoresistance |
| Grantee: | Angelo Brunelli Albertoni Laranjeira |
| Principal Investigator: | José Andrés Yunes |
| Institution: | Centro Infantil de Investigações Hematológicas Dr Domingos A Boldrini (CIB) |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 14/08247-8 - Preclinical studies of novel inhibitors of DNA methyltransferase in acute leukemia |
| Grantee: | Nathalia Moreno Cury |
| Principal Investigator: | José Andrés Yunes |
| Institution: | Centro Infantil de Investigações Hematológicas Dr Domingos A Boldrini (CIB) |
| Support Opportunities: | Scholarships in Brazil - Doctorate |