Abstract
The dual-specificity protein tyrosine phosphatases (DUSP) are members of the larger family of protein tyrosine phosphatases (PTPs) and have been implicated as central regulators of mitogenic and other signaling pathways mediated by the families of mitogen-activated protein kinases (MAPK). One of these MAPK phosphatases (MKPs) is the 185-amino acid long VHR, which was cloned based on its h…