CV Lattes
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Hospital do Câncer de Barretos (Institutional affiliation from the last research proposal) Birthplace: Portugal
Scientific Director of the Teaching and Research Institute (IEP); Coordinator of the Molecular Oncology Research Center (CPOM); and Scientific Director of the Molecular Diagnostic Laboratory at the Barretos Cancer Hospital, Barretos, SP. Brazil. Invited Associate Professor at the University of Minho School of Medicine (Braga, Portugal). Extraordinary Professor, Pan African Cancer Research Institute, University of Pretoria, South Africa. Graduation in biology, University of Porto (Portuga) l; doctorate in neuro-oncology, IARC (Lyon, France); postdoctoral fellow in cancer genomics, Free University Medical Center (Amsterdam, Netherlands) and IPATIMUP (Porto, Portugal). (Source: Lattes Curriculum)
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Medulloblastoma (MB) is the most common malignant brain tumor in children and is classified into four molecular subgroups: WNT, SHH, Group 3, and Group 4. Current treatment includes surgical resection, craniospinal irradiation, and chemotherapy. Although these therapies have improved survival rates, they cause severe and long-lasting side effects, highlighting the need for more effective …
Prostate cancer is the second leading cause of male cancer mortality in Brazil. In recent years, prostate-specific membrane antigen (PSMA)-targeted radioligand therapy has emerged as a promising option for patients suffering from mCRPC and do not respond to previously recommended therapies. Indeed, 45-60% of patients with mCRPC respond to 177Lu-PSMA therapy as demonstrated by several clin…
O VIII International Symposium on Translational Oncology é um evento de natureza científica e é organizado por pesquisadores e oncologistas do próprio instituto e visa oferecer oportunidades a um público formado por estudantes de Graduação, Mestrado e Doutorado, programas de Pós-Doutorado, Jovens Pesquisadores e médicos, de diferentes regiões do país, dando um especial destaque para a reg…
The Molecular Oncology Research center (CPOM) was officially opened in August 2010. The creation of this laboratory sought to meet the most demanding quality criteria, and the design of the project was made based on the most modern research centers, emphasizing the practicality of circulation, the ease of access to technological resources and the supervision of trained professionals.In Au…
Segundo a Organização Pan-Americana da Saúde o câncer é a segunda causa de morte no mundo sendo responsável em 2018 por 9,6 milhões de mortes, sendo que 70% ocorreram em países de baixa e média renda. Estimativas do Instituto Nacional do Câncer mostram para o biênio 2018-2019 uma incidência de 600 mil casos por ano no Brasil. Evidências científicas apontam grande contribuição da exposição…
(Only some records are available in English at this moment)
O bolsista TT-III será responsável por dar suporte técnico às atividades de experimentação animal do projeto, incluindo manutenção e genotipagem de colônias de camundongos transgênicos, planejamento e execução decruzamentos, e assistência nos experimentos in vivo, voltados à caracterização biológica e terapêutica domodelo SHH-MB Math1-Cre¿/¿:tch1^fl/fl. (AU)
Colorectal cancer (CCR) is the third most common type of cancer in the world, and in Brazil, it is the second most incident and despite early screening and new treatment strategies, it remains the second most fatal cancer in the world. The intestinal microbiota has been implicated in the development of colorectal cancer. The work of our group has identified the pathogenic role of Fusobact…
Glioblastoma (GBM) is the most common primary intracranial malignant tumor in adults. GBM is extremely invasive and aggressive, accounting for the majority of the 200,000 central nervous system (CNS) tumor-related deaths worldwide each year. GBM in children is relatively rare, with distinct molecular characteristics and response to treatment, when compared to adults. The current standard …
Glioblastoma (GBM) is one of the most common neoplasia of the central nervous system, is characterized as a highly aggressive and invasive tumor, is related to high mortality rates and a poor prognosis. Currently, the standard treatment of this disease consists of surgical removal of the tumor, followed by chemotherapy associated with the use of temozolomide (TMZ), a DNA alkylating agent.…
Lung cancer is responsible for 1 in 5 cancer deaths worldwide. The high number of deaths is due to the late diagnosis and the low effectiveness of therapeutic strategies. The pulmonary neoplasia can be divided into: non-small cells lung cancer (NSCLC), corresponding to 85% of cases, and small cell cancer. Histologically, it can be divided into: adenocarcinoma, squamous cell carcinoma and …
(Only some records are available in English at this moment)
Colorectal cancer (CRC) is a major global health burden, with high mortality rates due to late-stage diagnosis. Screening programs using fecal occult blood testing and colonoscopy aim to detect precursor lesions and CRC when curative treatment is feasible. However, these methods have limitations, including varying sensitivity and invasiveness. The gut microbiome has emerged as a potential…
High-grade gliomas (HGGs) are aggressive brain tumors characterized by rapid progression and resistance to conventional therapies, resulting in poor patient prognoses. To overcome these challenges, more sophisticated and representative preclinical models are required. This project has two main aims: first, to learn and develop advanced HGG preclinical models such as immunocompetent organo…
Glioblastoma is the most common and aggressive malignant central nervous system (CNS) tumor in adults. The standard protocol is surgery, radiotherapy and adjuvant/comcomitant chemotherapy with temozolomide. The cancer cells usually have resistance mechanisms against this chemotherapy agent, commonly associated with the DNA Repair pathways. To find a way out of this problem, we investiga…
(Only some records are available in English at this moment)