Abstract
Endocannabinoids are endogenous agonists of CB1 receptors that are also able to activate TRPV1 receptors when administered in high doses. Such profile may explain the biphasic responses observed in animal models, with compounds that act in the endocannabinoid system. In the forced swim test, CB1 agonists show potential antidepressant-like effect when administered in the ventral medial pre…