Abstract
The chromosomal abnormalities account for about 6% of cases of congenital anomalies, and the aneuploidies are the most commonly found. Among the autosomal aneuploidies, the most significant are the Down syndrome (Trisomy 21), Edwards (Trisomy 18) and Patau syndromes (Trisomy 13). Currently, the diagnosis of these diseases is performed by karyotype or FISH of fetal genetic material obtaine…