Abstract
The gaseous messenger hydrogen sulfide (H2S) has been described as a modulator of systemic inflammation (SI). H2S basal levels in the preoptic area of the hypothalamus (POA) has been found altered in animal models of SI; moreover, endogenous preoptic H2S has been shown to modulate fever. Interestingly, when SI is severe, a state of shock happens, being called 'endotoxic' shock that one in…