Juliana Dias Lourenço

• Abstract

  Although asthma and chronic obstructive pulmonary disease are described as distinct clinical entities, more recently, discussions about when COPD and asthma are expressions of the same disease that affects the respiratory system have intensified (1). The use of animal models helps to better understand the pathophysiological mechanisms involved in the development of different diseases, inc…

  The role of SOCS and STATs proteins in the differentiation of TCD4+ naive cells in an experimental model of Asthma and Chronic Obstructive Pulmonary Disease, BP.PD

• Abstract

  Smoking is considered the main risk factor for development of Chronic Obstructive Pulmonary Disease (COPD), however other intrinsic factors to the patient as well as the role of innate and adaptative immunity, are also involved in this process. In a previous study of our group, we demonstrated that the decrease of T regulatory (Treg) density cells, associated to lower density of IL-10 and…

  THE ROLE OF SOCS AND STATS PROTEINS ON THE DIFFERENTIATION OF TCD4+ NAIVE CELLS IN THE CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) DEVELOPMENT: COMPARATIVE ANLYSIS BETWEEN LOCAL AND SYSTEMIC IMMUNOLOGICAL RESPONSE, BP.DR

• Abstract

  Previous study in our laboratory showed that the treatment with BmTIA, a serinoprotease inhibitor, attenuated the alveolar destruction in mice submitted to a protocol of emphysema by porcine pancreatic elastase (PPE) instillation. Considering that the tabagism is the main factor for the DPOC development and that the cigarette smoke exposition is considered the best experimental model to…

  Treatment Evaluation with a serinoprotease inhibitor in a smoke-induced emphysema model, BP.MS

(Only some records are available in English at this moment)