Luis Octávio Regasini
CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de São José do Rio Preto. Instituto de Biociências, Letras e Ciências Exatas (IBILCE) (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduate at Farmácia Bioquímica from Universidade Estadual Paulista Júlio de Mesquita Filho (2003) and ph.d. at Chemistry from Universidade Estadual Paulista Júlio de Mesquita Filho (2008). Has experience in Pharmacy, acting on the following subjects: pterogyne nitens, inibidores de mieloperoxidase, fabaceae, antioxidante and alcalóides guanidínicos. (Source: Lattes Curriculum)
| News published in Agência FAPESP Newsletter about the researcher |
| Compounds isolated from rattlesnake venom show activity against hepatitis C virus |
- Synthesis and biological evaluation of Isobavachalcone (IBC) and analogs as potential agents against tuberculosis, AP.R
Abstract
Tuberculostatics are crucial drugs to for life expectancy, mainly to HIV-positive patients. Several reasons justify the need for new antimycobacterial, including high morbilitiy and mortality related to tuberculosis. The resurgence of multidrug resistant (MDR-TB) and extensively drug resistant (XDR-TB), typical morphophysiological features of Mycobacterium tuberculosis, as well as pheno...
- Protecting plants with antimicrobial peptides and gallates - Pro-Planta, AP.TEM
Abstract
Reducing the usage of pesticides is of great importance for a sustainable agriculture and bioeconomy. Insect pests and microbial pathogens are major causes of crop and fruit damages worldwide, representing losses of US$500 billion/year. Within the Pro-Planta proposal, two technologic platforms will be developed and evaluated to reduce the use of antimicrobials in citrus protection again...
- Third symposium on medicinal chemistry of UNESP (iii SIMQUIMED), AO.R
- Synthesis and biological evaluation of curcumin-cinnamaldehyde hybrids as bacterial cell division inhibitors, AP.R
Abstract
Antibacterial agents are crucial drugs for life expectancy. Several reasons justify the need by new antibacterials, including high bacterial resistance and mortality caused by infectious diseases. Thus, efforts are need to develop innovative antibacterial drugs. Recently, curcumin and cinnmaldehyde exhibited potent antibacterial activity against a broad panel of fungi. The central inter...
- 6th Congress of European microbiologists, AR.EXT
- Synthesis and evaluation of 4-Hydroxyderricini (4-HD) and its analogs as potential agents against tuberculosis, BP.MS
Abstract
uberculostatics are crucial drugs to for life expectancy, mainly to HIV-positive patients. Several reasons justify the need for new antimycobacterial, including high morbilitiy and mortality related to tuberculosis. The resurgence of multidrug resistant (MDR-TB) and extensively drug resistant (XDR-TB), typical morphophysiological features of Mycobacterium tuberculosis, as well as phenot...
- Investigation of curcumin analogues as agents against fungi that caused dermatological mycoses, BP.MS
Abstract
Superficial and cutaneous mycoses are fungal infections that affect the outer layer of the stratum corneum of the skin and its attachments. They are the most numerous and widespread group of all mycoses, affecting all age groups. Negative aesthetics is the first impact of superficial and cutaneous mycoses. However, these mycoses are not restricted to the aesthetic aspect, becoming a hea...
- Protecting plants with antimicrobial peptides and gallates: synthesis of alkyl gallates, BP.PD
Abstract
Within the thematic project Pro-Planta (FAPESP 2015/50162-2), we intended to synthesize seven alkyl gallates (scale of more than 50 grams), previously described by our group as potent inhibitors of Xanthomonas citri, the etiological agent of citrus canker (Silva et al., J. Bacteriol., v. 195, p. 85-94, 2013). Such compounds will be used to develop microgels able to attach to citrus tis...
- Investigation of chalcones against Staphylococcus aureus MSSA and MRSA: evaluation of antibacterial, antibiofilm, Anti-adsion activity and toxicity on Galleria Mellonella, BP.MS
Abstract
Staphylococcus aureus is a commensal microorganism and human pathogenic microorganism. Which is responsible by variety of diseases, incluing acne, endocarditis, boils, osteomyelitis, pustules, impetigo, meningitis, pneumonia and arthritis. Several bacterial agents have developed resistance. In the scientific initiation project developed by the candidate, conducted by two Fapesp processe...
- Preparation and Biological Evaluation of Dehydrozingerone Derivatives as Potential Agents agianst Tuberculosis, BP.MS
Abstract
Tuberculostatics are crucial drugs for maintaining life expectancy, mainly for HIV-positive patients. Numerous reasons justify the requirement for novel antimycobacterial agents, including the high resistance rates of Mycobacterium tuberculosis and rates of morbidity and mortality related to tuberculosis. Thus, efforts are need to discover and develop innovative tuberculostatics, which ...
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing research grants |
| 7 / 3 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 18 / 16 | Completed scholarships in Brazil |
| 29 / 23 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 16 |
| Citations | 104 |
| Cit./Article | 6.5 |
| Data from Web of Science | |
SILVA, GABRIEL; LIMA, FELIPE TEIXEIRA; SEBA, VIVIANE; MENDES LOURENCO, ANA LAURA; LUCAS, THAISE GRAMINHA; DE ANDRADE, BIANCA VIEIRA; TORREZAN, GUILHERME SILVA; POLAQUINI, CARLOS ROBERTO; GARCIA, MARCELO ENGRACIA; COUTO, LUCELIO BERNARDES; et al. Curcumin Analog CH-5 Suppresses the Proliferation, Migration, and Invasion of the Human Gastric Cancer Cell Line HGC-27. Molecules, v. 23, n. 2, FEB 2018. Web of Science Citations: 6. (14/18330-0, 14/15307-7, 17/03237-2)
NAZARE, ANA CAROLINA; POLAQUINI, CARLOS ROBERTO; CAVALCA, LUCIA BONCI; ANSELMO, DAIANE BERTHOLIN; CALMON SAIKI, MARILIA DE FREITAS; MONTEIRO, DIEGO ALVES; ZIELINSKA, ALEKSANDRA; RAHAL, PAULA; GOMES, ELENI; SCHEFFERS, DIRK-JAN; et al. Design of Antibacterial Agents: Alkyl Dihydroxybenzoates against Xanthomonas citri subsp citri. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 19, n. 10, OCT 2018. Web of Science Citations: 1. (15/50162-2, 17/50216-0, 13/50367-8, 14/18330-0)
KOPACZ, MALGORZATA M.; LORENZONI, ANDRE S. G.; POLAQUINI, CARLOS R.; REGASINI, LUIS O.; SCHEFFERS, DIRK-JAN. Purification and characterization of FtsZ from the citrus canker pathogen Xanthomonas citri subsp. citri. MICROBIOLOGYOPEN, v. 8, n. 5, MAY 2019. Web of Science Citations: 1. (13/50367-8, 14/18330-0)
SHIMIZU, JACQUELINE FARINHA; LIMA, CAROLINE SPRENGEL; PEREIRA, CARINA MACHADO; BITTAR, CINTIA; BATISTA, MARIANA NOGUEIRA; NAZARE, ANA CAROLINA; POLAQUINI, CARLOS ROBERTO; ZOTHNER, CARSTEN; HARRIS, MARK; RAHAL, PAULA; et al. Flavonoids from Pterogyne nitens Inhibit Hepatitis C Virus Entry. SCIENTIFIC REPORTS, v. 7, NOV 23 2017. Web of Science Citations: 3. (12/01403-9, 13/03897-1, 14/22198-0, 14/05445-3)
COQUEIRO, ALINE; REGASINI, LUIS OCTAVIO; STAPLETON, PAUL; BOLZANI, VANDERLAN DA SILVA; GIBBONS, SIMON. In Vitro Antibacterial Activity of Prenylated Guanidine Alkaloids from Pterogyne nitens and Synthetic Analogues. Journal of Natural Products, v. 77, n. 8, p. 1972-1975, AUG 2014. Web of Science Citations: 12. (06/61187-7, 03/00886-7)
SANTOS, MARIANA B.; PINHANELLI, VITOR C.; GARCIA, MAYARA A. R.; SILVA, GABRIEL; BAEK, SEUNG J.; FRANCA, SUZELEI C.; FACHIN, ANA L.; MARINS, MOZART; REGASINI, LUIS O.. Antiproliferative and pro-apoptotic activities of 2 `- and 4 `-aminochalcones against tumor canine cells. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v. 138, p. 884-889, SEP 29 2017. Web of Science Citations: 9. (14/18330-0, 14/15307-7)
CAMPOS, MONICA S.; SILVA, JOAO P. A.; LIMA, DANILO S.; REGASINI, LUIS O.; MARQUES, MARA RUBIA; BIANCARDI, MANOEL F.; TABOGA, SEBASTIAO R.; SANTOS, FERNANDA C. A.. Short-term exposure to chrysin promotes proliferative responses in the ventral male prostate and female prostate of adult gerbils. International Journal of Experimental Pathology, v. 100, n. 3, p. 192-201, JUN 2019. Web of Science Citations: 0. (14/18330-0)
POLAQUINI, CARLOS R.; MORAO, LUANA G.; NAZARE, ANA C.; TORREZAN, GUILHERME S.; DILARRI, GUILHERME; CAVALCA, LUCIA B.; CAMPOS, DEBORA L.; SILVA, ISABEL C.; PEREIRA, JESSE A.; SCHEFFERS, DIRK-JAN; et al. Antibacterial activity of 3,3 `-dihydroxycurcumin (DHC) is associated with membrane perturbation. BIOORGANIC CHEMISTRY, v. 90, n. SI, SEP 2019. Web of Science Citations: 0. (18/15083-2, 09/53989-4, 17/50216-0, 15/50162-2, 15/08089-6, 13/50367-8, 14/50880-0)
CAMPOS, MONICA S.; RIBEIRO, NAIARA C. S.; DE LIMA, RODRIGO F.; SANTOS, MARIANA B.; VILAMAIOR, PATRICIA S. L.; REGASINI, LUIS O.; BIANCARDI, MANOEL F.; TABOGA, SEBASTIAO R.; SANTOS, FERNANDA C. A.. Anabolic effects of chrysin on the ventral male prostate and female prostate of adult gerbils (Meriones unguiculatus). REPRODUCTION FERTILITY AND DEVELOPMENT, v. 30, n. 9, p. 1180-1191, AUG 2018. Web of Science Citations: 0. (14/18330-0)
PALANCO, ANA CERREJN; SINGULANI, JUNYA DE LACORTE; COSTA-ORLANDI, CAROLINE BARCELOS; GULLO, FERNANDA PATRICIA; STROHMAYER LOURENCETTI, NATALIA MANUELA; GOMES, PAULO CESAR; AYUSSO, GABRIELA MIRANDA; DUTRA, LUIZ ANTONIO; BOLZANI, VANDERLAN DA SILVA; REGASINI, LUIS OCTAVIO; et al. Activity of 3 `-hydroxychalcone against Cryptococcus gattii and toxicity, and efficacy in alternative animal models. FUTURE MICROBIOLOGY, v. 12, n. 13, p. 1123-1134, OCT 2017. Web of Science Citations: 9. (14/10446-9, 14/18330-0)
CAMPOS, MONICA S.; SILVA, JOAO P. A.; LIMA, DANILO S.; REGASINI, LUIS O.; MARQUES, MARA RUBIA; BIANCARDI, MANOEL F.; TABOGA, SEBASTIAO R.; SANTOS, FERNANDA C. A.. Short-term exposure to chrysin promotes proliferative responses in the ventral male prostate and female prostate of adult gerbils. International Journal of Experimental Pathology, v. 100, n. 3, p. 192-201, JUN 2019. Web of Science Citations: 0. (14/18330-0)
POLAQUINI, CARLOS R.; MORAO, LUANA G.; NAZARE, ANA C.; TORREZAN, GUILHERME S.; DILARRI, GUILHERME; CAVALCA, LUCIA B.; CAMPOS, DEBORA L.; SILVA, ISABEL C.; PEREIRA, JESSE A.; SCHEFFERS, DIRK-JAN; et al. Antibacterial activity of 3,3 `-dihydroxycurcumin (DHC) is associated with membrane perturbation. BIOORGANIC CHEMISTRY, v. 90, n. SI, SEP 2019. Web of Science Citations: 0. (18/15083-2, 09/53989-4, 17/50216-0, 15/50162-2, 15/08089-6, 13/50367-8, 14/50880-0)
MORAO, LUANA G.; POLAQUINI, CARLOS R.; KOPACZ, MALGORZATA; TORREZAN, GUILHERME S.; AYUSSO, GABRIELA M.; DILARRI, GUILHERME; CAVALCA, LUCIA B.; ZIELINSKA, ALEKSANDRA; SCHEFFERS, DIRK-JAN; REGASINI, LUIS O.; et al. A simplified curcumin targets the membrane of Bacillus subtilis. MICROBIOLOGYOPEN, v. 8, n. 4, APR 2019. Web of Science Citations: 2. (13/50367-8, 14/18330-0, 14/50880-0)
POLAQUINI, CARLOS R.; TORREZAN, GUILHERME S.; SANTOS, VANESSA R.; NAZARE, ANA C.; CAMPOS, DEBORA L.; ALMEIDA, LAIZA A.; SILVA, ISABEL C.; FERREIRA, HENRIQUE; PAVAN, FERNANDO R.; DUQUE, CRISTIANE; et al. Antibacterial and Antitubercular Activities of Cinnamylideneacetophenones. Molecules, v. 22, n. 10, OCT 2017. Web of Science Citations: 7. (14/18330-0, 16/06401-5)
COTINGUIBA, FERNANDO; REGASINI, LUIS OCTAVIO; BOLZANI, VANDERLAN DA SILVA; DEBONSI, HOSANA MARIA; PASSERINI, GABRIELA DUO; BARRETTO CICARELLI, REGINA MARIA; KATO, MASSUO JORGE; FURLAN, MAYSA. Piperamides and their derivatives as potential anti-trypanosomal agents. MEDICINAL CHEMISTRY RESEARCH, v. 18, n. 9, p. 703-711, DEC 2009. Web of Science Citations: 49. (03/00886-7)
RIBEIRO, NAIARA C. S.; CAMPOS, MONICA S.; SANTOS, MARIANA B.; AYUSSO, GABRIELA M.; VILAMAIOR, PATRICIA S. L.; REGASINI, LUIS O.; TABOGA, SEBASTIAO R.; BIANCARDI, MANOEL F.; PEREZ, ANA P. S.; SANTOS, FERNANDA C. A.. Prepubertal chrysin exposure upregulates either AR in male ventral prostate or AR and ER alpha in Skene's paraurethral gland of pubertal and adult gerbils. Fitoterapia, v. 124, p. 137-144, JAN 2018. Web of Science Citations: 3. (14/18330-0)
(References retrieved automatically from State of São Paulo Research Institutions)
AYUSSO, Gabriela Miranda. Síntese e avaliação de análogos monocetônicos de curcumina como potenciais agentes contra a tuberculose. 2019. 171f. Dissertação (Mestrado) - . Universidade Estadual Paulista "Júlio de Mesquita Filho" Instituto de Biociências, Letras e Ciências Exatas.
NAZARÉ, Ana Carolina. Preparação e avaliação de diidroxibenzoatos de alquila contra xanthomonas citri subsp. citri e no controle do cancro cítrico. 2019. 185f. Tese (Doutorado) – . Universidade Estadual Paulista "Júlio de Mesquita Filho" Instituto de Biociências, Letras e Ciências Exatas.
REGASINI, Luis Octávio. Estudo químico de Pterogyne nitens (Caesalpinioideae), síntese e potencial farmacológico de alcalóides guanidínicos e análogos. 2008. 232f. Tese (Doutorado) – Campus de Araraquara. Universidade Estadual Paulista (UNESP). Araraquara.
ASSIS, Leticia Ribeiro de. Síntese e avaliação biológica de novos híbridos tuberculostático-chalcona como potenciais agentes contra a tuberculose. 2017. 168f. Dissertação (Mestrado) - Universidade Estadual Paulista "Júlio de Mesquita Filho" Instituto de Biociências Letras e Ciências Exatas, São José do Rio Preto.
MARQUES, Beatriz de Carvalho. Atividade antibacteriana de híbridos curcumina-cinamaldeído contra células planctônicas e biofilmes de MSSA e MRSA. 2019. 165f. Dissertação (Mestrado) - . Universidade Estadual Paulista "Júlio de Mesquita Filho" Instituto de Biociências, Letras e Ciências Exatas.
SANTOS, Mariana Bastos dos. Híbridos chalcona-inibidores de histona desacetilase como agentes antiproliferativos : síntese e avaliação em células de mama e em histona desacetilases. 2019. 159f. Tese (Doutorado) – . Universidade Estadual Paulista "Júlio de Mesquita Filho" Instituto de Biociências, Letras e Ciências Exatas.