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Luis Octávio Regasini

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Universidade Estadual Paulista (UNESP). Campus de São José do Rio Preto. Instituto de Biociências, Letras e Ciências Exatas (IBILCE)  (Institutional affiliation for the last research proposal)
Birthplace: Brazil

Luis Octávio Regasini in research grants and scholarships supported by FAPESP.

News published in Agência FAPESP Newsletter about the researcher
Compounds isolated from rattlesnake venom show activity against hepatitis C virus 
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Use this Research Supported by FAPESP (BV/FAPESP) channel only to send messages referring to FAPESP-funded scientific projects.


 

 

 

 

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Scientific publications resulting from Research Grants and Scholarships under the grantee's responsibility (36)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

Publications36
Citations359
Cit./Article10.0
Data from Web of Science

TAJIMA, YASUHIRO; MURASE, HAYATO; SATAKE, KAZUHIRO; MITANI, YUJI; REGASINI, LUIS OCTAVIO; BOLZANI, VANDERLAN DA SILVA; EFFERTH, THOMAS; NAKAGAWA, HIROSHI. Nitensidine A, a guanidine alkaloid from Pterogyne nitens, induces osteoclastic cell death. Cytotechnology, v. 67, n. 4, SI, p. 585-592, . Web of Science Citations: 3. (03/02176-7)

ZERAIK, MARIA LUIZA; PETRONIO, MAICON S.; COELHO, DYOVANI; REGASINI, LUIS OCTAVIO; SILVA, DULCE H. S.; DA FONSECA, LUIZ MARCOS; MACHADO, SERGIO A. S.; BOLZANI, VANDERLAN S.; XIMENES, VALDECIR F.. Improvement of Pro-Oxidant Capacity of Protocatechuic Acid by Esterification. PLoS One, v. 9, n. 10, . Web of Science Citations: 9. (11/03017-6, 13/07600-3, 13/08784-0)

NAZARE, ANA CAROLINA; POLAQUINI, CARLOS ROBERTO; CAVALCA, LUCIA BONCI; ANSELMO, DAIANE BERTHOLIN; CALMON SAIKI, MARILIA DE FREITAS; MONTEIRO, DIEGO ALVES; ZIELINSKA, ALEKSANDRA; RAHAL, PAULA; GOMES, ELENI; SCHEFFERS, DIRK-JAN; et al. Design of Antibacterial Agents: Alkyl Dihydroxybenzoates against Xanthomonas citri subsp citri. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 19, n. 10, . Web of Science Citations: 1. (17/50216-0, 15/50162-2, 13/50367-8, 14/18330-0)

MARQUES, BEATRIZ C.; SANTOS, MARIANA B.; ANSELMO, DAIANE B.; MONTEIRO, DIEGO A.; GOMES, ELENI; SAIKI, MARILIA F. C.; RAHAL, PAULA; ROSALEN, PEDRO L.; SARDI, JANAINA C. O.; REGASINI, LUIS O.. Methoxychalcones: Effect of Methoxyl Group on the Antifungal Antibacterial and Antiproliferative Activities. Medicinal Chemistry, v. 16, n. 7, p. 881-891, . Web of Science Citations: 0. (14/18330-0, 17/09245-7, 14/18577-5, 09/53989-4, 18/15083-2, 16/08084-7, 14/50926-0)

KOPACZ, MALGORZATA M.; LORENZONI, ANDRE S. G.; POLAQUINI, CARLOS R.; REGASINI, LUIS O.; SCHEFFERS, DIRK-JAN. Purification and characterization of FtsZ from the citrus canker pathogen Xanthomonas citri subsp. citri. MICROBIOLOGYOPEN, v. 8, n. 5, . Web of Science Citations: 1. (13/50367-8, 14/18330-0)

TORREZAN, GUILHERME SILVA; POLAQUINI, CARLOS ROBERTO; LIMA, MARCELO FREITAS; REGASINI, LUIS OCTAVIO. Use of glycerol, waste glycerol from biodiesel production and other protic solvents in bioactive alpha, beta-unsaturated ketones synthesis. SUSTAINABLE CHEMISTRY AND PHARMACY, v. 16, . Web of Science Citations: 0. (18/15083-2, 09/53989-4, 14/50926-0, 14/18330-0)

SHIMIZU, JACQUELINE FARINHA; LIMA, CAROLINE SPRENGEL; PEREIRA, CARINA MACHADO; BITTAR, CINTIA; BATISTA, MARIANA NOGUEIRA; NAZARE, ANA CAROLINA; POLAQUINI, CARLOS ROBERTO; ZOTHNER, CARSTEN; HARRIS, MARK; RAHAL, PAULA; et al. Flavonoids from Pterogyne nitens Inhibit Hepatitis C Virus Entry. SCIENTIFIC REPORTS, v. 7, . Web of Science Citations: 3. (14/22198-0, 13/03897-1, 12/01403-9, 14/05445-3)

SILVA, GABRIEL; LIMA, FELIPE TEIXEIRA; SEBA, VIVIANE; MENDES LOURENCO, ANA LAURA; LUCAS, THAISE GRAMINHA; DE ANDRADE, BIANCA VIEIRA; TORREZAN, GUILHERME SILVA; POLAQUINI, CARLOS ROBERTO; GARCIA, MARCELO ENGRACIA; COUTO, LUCELIO BERNARDES; et al. Curcumin Analog CH-5 Suppresses the Proliferation, Migration, and Invasion of the Human Gastric Cancer Cell Line HGC-27. Molecules, v. 23, n. 2, . Web of Science Citations: 6. (17/03237-2, 14/15307-7, 14/18330-0)

GABRIELA ALVES LICURSI VIEIRA; MARCO TÚLIO ALVES DA SILVA; LUIS OCTÁVIO REGASINI; FERNANDO COTINGUIBA; HELEN JULIE LAURE; JOSÉ CÉSAR ROSA; MAYSA FURLAN; REGINA MARIA BARRETTO CICARELLI. Trypanosoma cruzi: analysis of two different strains after piplartine treatment. Brazilian Journal of Infectious Diseases, v. 22, n. 3, p. -, . (11/24017-4, 07/02076-3)

LICURSI VIEIRA, GABRIELA ALVES; ALVES DA SILVA, MARCO TULIO; REGASINI, LUIS OCTAVIO; COTINGUIBA, FERNANDO; LAURE, HELEN JULIE; ROSA, JOSE CESAR; FURLAN, MAYSA; BARRETTO CICARELLI, REGINA MARIA. Trypanosoma cruzi: analysis of two different strains Check for after piplartine treatment. Brazilian Journal of Infectious Diseases, v. 22, n. 3, p. 208-218, . Web of Science Citations: 1. (11/24017-4, 07/02076-3)

TORREZAN, GUILHERME SILVA; POLAQUINI, CARLOS ROBERTO; LIMA, MARCELO FREITAS; REGASINI, LUIS OCTAVIO. Use of glycerol, waste glycerol from biodiesel production and other protic solvents in bioactive alpha, beta-unsaturated ketones synthesis. SUSTAINABLE CHEMISTRY AND PHARMACY, v. 16, . Web of Science Citations: 0. (18/15083-2, 09/53989-4, 14/50926-0, 14/18330-0)

TAJIMA, YASUHIRO; MURASE, HAYATO; SATAKE, KAZUHIRO; MITANI, YUJI; REGASINI, LUIS OCTAVIO; BOLZANI, VANDERLAN DA SILVA; EFFERTH, THOMAS; NAKAGAWA, HIROSHI. Nitensidine A, a guanidine alkaloid from Pterogyne nitens, induces osteoclastic cell death. Cytotechnology, v. 67, n. 4, SI, p. 585-592, . Web of Science Citations: 3. (03/02176-7)

ZERAIK, MARIA LUIZA; PETRONIO, MAICON S.; COELHO, DYOVANI; REGASINI, LUIS OCTAVIO; SILVA, DULCE H. S.; DA FONSECA, LUIZ MARCOS; MACHADO, SERGIO A. S.; BOLZANI, VANDERLAN S.; XIMENES, VALDECIR F.. Improvement of Pro-Oxidant Capacity of Protocatechuic Acid by Esterification. PLoS One, v. 9, n. 10, . Web of Science Citations: 9. (11/03017-6, 13/08784-0, 13/07600-3)

TAJIMA, YASUHIRO; NAKAGAWA, HIROSHI; TAMURA, AI; KADIOGLU, ONAT; SATAKE, KAZUHIRO; MITANI, YUJI; MURASE, HAYATO; REGASINI, LUIS OCTAVIO; BOLZANI, VANDERLAN DA SILVA; ISHIKAWA, TOSHIHISA; et al. Nitensidine A, a guanidine alkaloid from Pterogyne nitens, is a novel substrate for human ABC transporter ABCB1. Phytomedicine, v. 21, n. 3, p. 323-332, . Web of Science Citations: 22. (03/02176-7)

COQUEIRO, ALINE; REGASINI, LUIS OCTAVIO; STAPLETON, PAUL; BOLZANI, VANDERLAN DA SILVA; GIBBONS, SIMON. In Vitro Antibacterial Activity of Prenylated Guanidine Alkaloids from Pterogyne nitens and Synthetic Analogues. Journal of Natural Products, v. 77, n. 8, p. 1972-1975, . Web of Science Citations: 12. (03/00886-7, 06/61187-7)

OLIVEIRA, CAMILA M.; SILVA, GERALDO H.; REGASINI, LUIS O.; ZANARDI, LISINEIA M.; EVANGELISTA, ALANA H.; YOUNG, MARIA C. M.; BOLZANI, VANDERLAN S.; ARAUJO, ANGELA R.. Bioactive Metabolites Produced by Penicillium sp.1 and sp.2, Two Endophytes Associated with Alibertia macrophylla (Rubiaceae). ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES, v. 64, n. 11-12, p. 824-830, . Web of Science Citations: 21. (03/02176-7)

PASSALACQUA, THAIS GABAN; DUTRA, LUIZ ANTONIO; DE ALMEIDA, LETICIA; ARENAS VELASQUEZ, ANGELA MARIA; ESTEVES TORRES, FABIO AURELIO; YAMASAKI, PAULO RENATO; DOS SANTOS, MARIANA BASTOS; REGASINI, LUIS OCTAVIO; MICHELS, PAUL A. M.; BOLZANI, VANDERLAN DA SILVA; et al. Synthesis and evaluation of novel prenylated chalcone derivatives as anti-leishmanial and anti-trypanosomal compounds. Bioorganic & Medicinal Chemistry Letters, v. 25, n. 16, p. 3342-3345, . Web of Science Citations: 28. (10/16732-2)

MORAO, LUANA G.; LORENZONI, ANDRE S. G.; CHAKRABORTY, PARICHITA; AYUSSO, GABRIELA M.; CAVALCA, LUCIA B.; SANTOS, MARIANA B.; MARQUES, BEATRIZ C.; DILARRI, GUILHERME; ZAMUNER, CAIO; REGASINI, LUIS O.; et al. Investigating the Modes of Action of the Antimicrobial Chalcones BC1 and T9A. Molecules, v. 25, n. 20, . Web of Science Citations: 0. (16/07108-0, 17/50216-0, 14/18577-5, 14/18330-0, 18/15083-2, 16/08084-7, 14/18719-4)

CAMPOS, MONICA S.; SILVA, JOAO P. A.; LIMA, DANILO S.; REGASINI, LUIS O.; MARQUES, MARA RUBIA; BIANCARDI, MANOEL F.; TABOGA, SEBASTIAO R.; SANTOS, FERNANDA C. A.. Short-term exposure to chrysin promotes proliferative responses in the ventral male prostate and female prostate of adult gerbils. International Journal of Experimental Pathology, v. 100, n. 3, p. 192-201, . Web of Science Citations: 0. (14/18330-0)

POLAQUINI, CARLOS R.; MORAO, LUANA G.; NAZARE, ANA C.; TORREZAN, GUILHERME S.; DILARRI, GUILHERME; CAVALCA, LUCIA B.; CAMPOS, DEBORA L.; SILVA, ISABEL C.; PEREIRA, JESSE A.; SCHEFFERS, DIRK-JAN; et al. Antibacterial activity of 3,3 `-dihydroxycurcumin (DHC) is associated with membrane perturbation. BIOORGANIC CHEMISTRY, v. 90, n. SI, . Web of Science Citations: 0. (18/15083-2, 09/53989-4, 17/50216-0, 15/50162-2, 15/08089-6, 13/50367-8, 14/50880-0)

RIBEIRO, NAIARA C. S.; CAMPOS, MONICA S.; SANTOS, MARIANA B.; AYUSSO, GABRIELA M.; VILAMAIOR, PATRICIA S. L.; REGASINI, LUIS O.; TABOGA, SEBASTIAO R.; BIANCARDI, MANOEL F.; PEREZ, ANA P. S.; SANTOS, FERNANDA C. A.. Prepubertal chrysin exposure upregulates either AR in male ventral prostate or AR and ER alpha in Skene's paraurethral gland of pubertal and adult gerbils. Fitoterapia, v. 124, p. 137-144, . Web of Science Citations: 3. (14/18330-0)

LIMA, FELIPE TEIXEIRA; SEBA, VIVIANE; SILVA, GABRIEL; TORREZAN, GUILHERME SILVA; POLAQUINI, CARLOS ROBERTO; PINHANELLI, VITOR CARESSATO; BAEK, SEUNG J.; FACHIN, ANA LUCIA; REGASINI, LUIS OCTAVIO; MARINS, MOZART. The Curcumin Analog CH-5 Exerts Anticancer Effects in Human Osteosarcoma Cells via Modulation of Transcription Factors p53/Sp1. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 19, n. 7, . Web of Science Citations: 1. (14/15307-7, 14/18330-0, 17/03237-2)

CAMPOS, MONICA S.; RIBEIRO, NAIARA C. S.; DE LIMA, RODRIGO F.; SANTOS, MARIANA B.; VILAMAIOR, PATRICIA S. L.; REGASINI, LUIS O.; BIANCARDI, MANOEL F.; TABOGA, SEBASTIAO R.; SANTOS, FERNANDA C. A.. Anabolic effects of chrysin on the ventral male prostate and female prostate of adult gerbils (Meriones unguiculatus). REPRODUCTION FERTILITY AND DEVELOPMENT, v. 30, n. 9, p. 1180-1191, . Web of Science Citations: 0. (14/18330-0)

DOS SANTOS, MARIANA BASTOS; ANSELMO, DAIANE BERTHOLIN; DE OLIVEIRA, JESSICA GISLEINE; JARDIM-PERASSI, BRUNA V.; MONTEIRO, DIEGO ALVES; SILVA, GABRIEL; GOMES, ELENI; FACHIN, ANA LUCIA; MARINS, MOZART; PIRES DE CAMPOS ZUCCARI, DEBORA APARECIDA; et al. Antiproliferative activity and p53 upregulation effects of chalcones on human breast cancer cells. Journal of Enzyme Inhibition and Medicinal Chemistry, v. 34, n. 1, p. 1093-1099, . Web of Science Citations: 1. (14/18330-0, 18/15083-2)

PALANCO, ANA CERREJN; SINGULANI, JUNYA DE LACORTE; COSTA-ORLANDI, CAROLINE BARCELOS; GULLO, FERNANDA PATRICIA; STROHMAYER LOURENCETTI, NATALIA MANUELA; GOMES, PAULO CESAR; AYUSSO, GABRIELA MIRANDA; DUTRA, LUIZ ANTONIO; BOLZANI, VANDERLAN DA SILVA; REGASINI, LUIS OCTAVIO; et al. Activity of 3 `-hydroxychalcone against Cryptococcus gattii and toxicity, and efficacy in alternative animal models. FUTURE MICROBIOLOGY, v. 12, n. 13, p. 1123-1134, . Web of Science Citations: 9. (14/18330-0, 14/10446-9)

POLAQUINI, CARLOS R.; TORREZAN, GUILHERME S.; SANTOS, VANESSA R.; NAZARE, ANA C.; CAMPOS, DEBORA L.; ALMEIDA, LAIZA A.; SILVA, ISABEL C.; FERREIRA, HENRIQUE; PAVAN, FERNANDO R.; DUQUE, CRISTIANE; et al. Antibacterial and Antitubercular Activities of Cinnamylideneacetophenones. Molecules, v. 22, n. 10, . Web of Science Citations: 7. (14/18330-0, 16/06401-5)

MORAO, LUANA G.; POLAQUINI, CARLOS R.; KOPACZ, MALGORZATA; TORREZAN, GUILHERME S.; AYUSSO, GABRIELA M.; DILARRI, GUILHERME; CAVALCA, LUCIA B.; ZIELINSKA, ALEKSANDRA; SCHEFFERS, DIRK-JAN; REGASINI, LUIS O.; et al. A simplified curcumin targets the membrane of Bacillus subtilis. MICROBIOLOGYOPEN, v. 8, n. 4, . Web of Science Citations: 2. (13/50367-8, 14/50880-0, 14/18330-0)

DE OLIVEIRA, CAMILA MARTINS; SILVA, GERALDO HUMBERTO; REGASINI, LUIS OCTAVIO; FLAUSINO, JR., OTAVIO; NOELI LOPEZ, SILVIA; ABISSI, BARBARA MARCONDES; DE SOUZA BERLINCK, ROBERTO GOMES; SETTE, LARA DURAES; BONUGLI-SANTOS, RAFAELLA COSTA; RODRIGUES, ANDRE; et al. Xylarenones C-E from an Endophytic Fungus Isolated from Alibertia macrophylla. Journal of Natural Products, v. 74, n. 6, p. 1353-1357, . Web of Science Citations: 9. (03/02176-7)

LOPES, ADRIANA APARECIDA; LOPEZ, SILVIA NOELI; REGASINI, LUIS OCTAVIO; BATISTA JUNIOR, JOAO MARCOS; AMBROSIO, DANIELA LUZ; KATO, MASSUO JORGE; BOLZANI, VANDERLAN DA SILVA; BARRETTO CICARELLI, REGINA MARIA; FURLAN, MAYSA. In vitro activity of compounds isolated from Piper crassinervium against Trypanosoma cruzi. NATURAL PRODUCT RESEARCH, v. 22, n. 12, p. 1040-1046, . Web of Science Citations: 24. (06/50086-5, 03/01867-6)

SERRANO, MARIA A. R.; PIVATTO, MARCOS; FRANCISCO, WELINGTON; DANUELLO, AMANDA; REGASINI, LUIS O.; LOPES, ELAINE M. C.; LOPES, MARCIA N.; YOUNG, MARIA C. M.; BOLZANI, VANDERLAN S.. Acetylcholinesterase Inhibitory Pyridine Alkaloids of the Leaves of Senna multijuga. Journal of Natural Products, v. 73, n. 3, SI, p. 482-484, . Web of Science Citations: 9. (03/02176-7)

COTINGUIBA, FERNANDO; REGASINI, LUIS OCTAVIO; BOLZANI, VANDERLAN DA SILVA; DEBONSI, HOSANA MARIA; PASSERINI, GABRIELA DUO; BARRETTO CICARELLI, REGINA MARIA; KATO, MASSUO JORGE; FURLAN, MAYSA. Piperamides and their derivatives as potential anti-trypanosomal agents. MEDICINAL CHEMISTRY RESEARCH, v. 18, n. 9, p. 703-711, . Web of Science Citations: 49. (03/00886-7)

NAVICKIENE, HOSANA M. DEBONSI; MORANDIM, ANDRÉIA DE A.; ALÉCIO, ALBERTO C.; REGASINI, LUÍS O.; BERGAMO, DEBORA CRISTINA B.; TELASCREA, MARCELO; CAVALHEIRO, ALBERTO J.; LOPES, MÁRCIA N.; BOLZANI, VANDERLAN DA S.; FURLAN, MAYSA; et al. Composition and antifungal activity of essential oils from Piper aduncum, Piper arboreum and Piper tuberculatum. Química Nova, v. 29, n. 3, p. 467-470, .

MASCIA LOPES, FLAVIA CRISTINE; ROCHA, ANA; PIRRACO, ANA; REGASINI, LUIS O.; SIQUEIRA, JANAINA R.; SILVA, DULCE H. S.; BOLZANI, VANDERLAN S.; CARLOS, IRACILDA Z.; SOARES, RAQUEL. Alchornea glandulosa Ethyl Acetate Fraction Exhibits Antiangiogenic Activity: Preliminary Findings from In Vitro Assays Using Human Umbilical Vein Endothelial Cells. JOURNAL OF MEDICINAL FOOD, v. 14, n. 10, p. 1244-1253, . Web of Science Citations: 5. (03/02176-7)

FLAUSINO, JR., O. A.; DUFAU, L.; REGASINI, L. O.; PETRONIO, M. S.; SILVA, D. H. S.; ROSE, T.; BOLZANI, V. S.; REBOUD-RAVAUX, M.. Alkyl Hydroxybenzoic Acid Derivatives that Inhibit HIV-1 Protease Dimerization. Current Medicinal Chemistry, v. 19, n. 26, p. 4534-4540, . Web of Science Citations: 9. (04/07932-7, 03/02176-7)

FRANCISCO, WELINGTON; PIVATTO, MARCOS; DANUELLO, AMANDA; REGASINI, LUIS O.; BACCINI, LUCIENE R.; YOUNG, MARIA C. M.; LOPES, NORBERTO P.; LOPES, JOAO L. C.; BOLZANI, VANDERLAN S.. Pyridine Alkaloids from Senna multijuga As Acetylcholinesterase Inhibitors. Journal of Natural Products, v. 75, n. 3, p. 408-413, . Web of Science Citations: 13. (03/02176-7)

SATAKE, KAZUHIRO; TSUKAMOTO, MEGUMI; MITANI, YUJI; REGASINI, LUIS OCTAVIO; BOLZANI, VANDERLAN DA SILVA; EFFERTH, THOMAS; NAKAGAWA, HIROSHI. Human ABCB1 confers cells resistance to cytotoxic guanidine alkaloids from Pterogyne nitens. BIO-MEDICAL MATERIALS AND ENGINEERING, v. 25, n. 3, p. 249-256, . Web of Science Citations: 2. (03/02176-7)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

AYUSSO, Gabriela Miranda. Síntese e avaliação de análogos monocetônicos de curcumina como potenciais agentes contra a tuberculose.  171 f. Dissertação (Mestrado) -  Universidade Estadual Paulista "Júlio de Mesquita Filho" Instituto de Biociências, Letras e Ciências Exatas.  (17/08383-7

NAZARÉ, Ana Carolina. Preparação e avaliação de diidroxibenzoatos de alquila contra xanthomonas citri subsp. citri e no controle do cancro cítrico.  185 f. Tese (Doutorado) -  Universidade Estadual Paulista "Júlio de Mesquita Filho" Instituto de Biociências, Letras e Ciências Exatas.  (15/08089-6

PATTINI, Veridianna Camilo. Investigação de análogos de curcumina como agentes contra fungos causadores de dermatomicoses. Dissertação (Mestrado) -  Universidade Estadual Paulista "Júlio de Mesquita Filho" Instituto de Biociências, Letras e Ciências Exatas.  (18/08994-9

MARQUES, Beatriz de Carvalho. Atividade antibacteriana de híbridos curcumina-cinamaldeído contra células planctônicas e biofilmes de MSSA e MRSA.  165 f. Dissertação (Mestrado) -  Universidade Estadual Paulista "Júlio de Mesquita Filho" Instituto de Biociências, Letras e Ciências Exatas.  (17/09245-7

ASSIS, Leticia Ribeiro de. Síntese e avaliação biológica de novos híbridos tuberculostático-chalcona como potenciais agentes contra a tuberculose.  168 f. Dissertação (Mestrado) -  Universidade Estadual Paulista "Júlio de Mesquita Filho" Instituto de Biociências Letras e Ciências Exatas, São José do Rio Preto.  (15/09969-0

REGASINI, Luis Octávio. Estudo químico de Pterogyne nitens (Caesalpinioideae), síntese e potencial farmacológico de alcalóides guanidínicos e análogos.  232 f. Tese (Doutorado) -  Campus de Araraquara.  Universidade Estadual Paulista (UNESP).  Araraquara.  (03/00886-7

SANTOS, Mariana Bastos dos. Híbridos chalcona-inibidores de histona desacetilase como agentes antiproliferativos : síntese e avaliação em células de mama e em histona desacetilases.  159 f. Tese (Doutorado) -  Universidade Estadual Paulista "Júlio de Mesquita Filho" Instituto de Biociências, Letras e Ciências Exatas.  (16/00580-5

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