Graduate at Química (Bacharelado) from Universidade Federal de São Carlos (2002) and pHD at Quimica Orgânica from Universidade Estadual Paulista Júlio de Mesquita Filho (2008). Has experience in Chemistry, focusing on Natural Products and Natural Products Biosynthesis. (Source: Lattes Curriculum)
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Plants, microbes and insects produce complex small molecules, called "natural products". Given the energy that the organism must expend to produce these molecules, natural products likely confer an evolutionary advantage for the producing organism. Therefore, most natural products have some type of biological activity. For our purposes, this means that these metabolites are a rich resourc…
Natural product derivatives or "unnatural products" are known to play a substantial role in drug discovery. Nowadays, there are about 200 pharmaceuticals fluorine containing into various heterocyclic scaffolds and the presence of fluorine atoms within their structures increase the therapeutic efficacy and pharmacological properties. Metabolic engineering strategies to generate "unnatural"…
Biosynthetic investigation of quinonemethide triterpenoid 22b-hydroxy-maytenin (2) from in vitro root cultures of Peritassa laevigata (Celastraceae) was conducted using 13C-precursor. The mevalonate pathway in P. laevigata is responsible for the synthesis of the quinonemethide triterpenoid scaffold. Moreover, anatomical analysis of P. laevigata roots cultured in vitro and in situ showed t…
(Only some records are available in English at this moment)
Patchouli (Pogostemon cablin) is an aromatic species that belongs to the Lamiaceae family. Patchouli essential oil is used commercially in the perfumery, cosmetics, and aromatherapy industries around the world. The main compound for this characteristic and the typical note of its essential oil is patchoulol or patchouli alcohol. In addition to being used in cosmetics, it is used as an ant…
Eleutherine plicata is a Brazilian species widely used in regions of tropical America, with great use in the Brazilian Amazon region. Phytochemical studies carried out with E. plicata suggested that isoeleuterin and eleuterin are the major naphthoquinones produced by the species, and can serve as chemical markers. Recent studies showed that the extract and fractions of this species were p…
Asteraceae family. E. prostata has several popular names, such as false daisy, watercress, button herb, lancet herb, surucuína, coacica and tangeracá. Cumestanes (wedelolactone and demethylwedelolactone), flavonoids (luteolin and apigenin) and polyphenols are the main bioactive constituents of the species. In recent years, authors have shown some strategies to explore the chemical diversi…
(Only some records are available in English at this moment)
Humans have a long history of plant dependence, for example, for food supply, and especially as adjuncts in the diseases' treatment. In the past and today, several drugs are designed from plant metabolites and novel scaffolds are constantly being identified. However, the plant source has often production compromised and in vitro plant cultures ensure the production of crude extracts, for …
Chemical structures of several natural products, and especially their derivatives, can be promising candidates for novel drugs. Natural products diversification can occur through many strategies of structural modification such as; semi-synthesis, biotransformation, and precursor-directed biosynthesis. This project aims the molecular modification by precursor-directed biosynthesis, which i…
Plants, microorganisms and insects biosynthesize small complex molecules, called "natural products". For our purposes, this means that these metabolites are a rich resource for a wide range of applications, including the development of pharmaceuticals, insecticides, herbicides, biomaterials and sources of bioenergy. Secondary metabolites called "alkaloids" are promising agents in the face…
(Only some records are available in English at this moment)
Monoterpene indole alkaloids (MIAs) are alkaloid-type natural products that exhibit huge structural chemical diversity. Some alkaloids exhibit remarkable biological action, including the oxindole (anti-inflammatory and anti-cancer), quinoline (anti-malarial) and iboga (neurological disorders and anti-addiction agent). If we understand the metabolic, or biosynthesis, pathway that the plant…
| 6 / 5 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 16 / 11 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 27 / 21 | All research grants and scholarships |
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CV Lattes
ORCID