CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
She holds a Ph.D. in Infectious Diseases from the Faculty of Medicine at the University of São Paulo and completed postdoctoral training at the Federal University of São Paulo. She is currently a Professor at the Institute for Research and Education in Health of São Paulo (IPESSP). Her research is dedicated to the study of viral diversity and molecular epidemiology, with emphasis on the application of advanced molecular methodologies. She has established expertise in next-generation sequencing, real-time PCR, and research and development, with particular interest in NeuroAIDS. (Source: Lattes Curriculum)
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Despite advances in prevention and testing programs a large proportion of individuals seeking first care to HIV / AIDS, whether in Anonymous Testing Centers (CTAs) and in hospitals, already have advanced HIV infection. Late diagnosis is closely related to ethnicity, gender, immigration and low educational socioeconomic status. In Brazil, besides these factors we have reported on studies t…
Although antiretroviral therapy is capable of controlling the replication of HIV-1, the major difficulty in the eradication of infection is the establishment of stable viral reservoirs in infected cells. These reservoirs are maintained in part by epigenetic modifications that regulates the latent infection and reactivation of the provirus. One of the epigenetic mechanisms involved in this…
Highly Active Antiretroviral Therapy (HAART) was introduced in 1996 and reduced both the mortality and morbidity of HIV-1 infected patients. However, HAART may lead to emergence of drug-resistant viral populations because of the the selective pressure of drugs. These viral populations arise from the lack of patient adherence to treatment, pharmacokinetics dependent of host genetics, prese…
(Only some records are available in English at this moment)
Human Immunodeficiency Virus (HIV) is the etiologic agent of Acquired Immunodeficiency Syndrome (AIDS). The envelope of the virus contains the glycoprotein 120 (gp120) which is formed by five constant regions and five variables, among which is the V3 loop. The V3 loop / region is formed by 35 amino acids being one of the main targets of the immune system and at its top (motif) has an amin…
The Vitamin D is a lipid soluble hormone that has the principal function of calcio homeostasis, to ensure bone and brain health development. Recent studies demonstrate that it even has other roles in important systems like immunologic and cardiovascular, beyond your possible connection with cancer. All these functions are mediated by a nuclear receptor, the VDR (vitamin D receptor), which…
Nearly 8% of the human genome is formed by human endogenous retroviruses (HERVs) that integrates randomly into the host genome, which can cause deleterious mutations; therefore there are protection mechanisms against such integration as: silencing by methylation of DNA and / or changes in chromatin; production of interference RNA and the action of the enzymes from the APOBEC3´s family. Th…
(Only some records are available in English at this moment)
| 6 | Completed research grants |
| 10 | Completed scholarships in Brazil |
| 16 | All research grants and scholarships |
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