Débora Campanella Bastos

• Abstract

  The fatty acid synthase enzyme (FASN, E.C. 2.3.1.85) is responsible for endogenous synthesis of fatty acids, especially palmitate, from acetyl-CoA and malonyl-CoA. FASN is overexpressed in several human malignancies, including oral squamous cell carcinoma (OSCC), in which is also associated with the worse prognosis. FASN structure contains two polypeptide chains (H 270 kDa each) containin…

  Effects of inhibition of the fatty acid synthase enzyme by nanoencapsulated compounds and overexpression of catalytic mutants on the malignant phenotype of oral squamous cell carcinoma cells, AP.R

• Abstract

  Oral squamous cell carcinoma (OSCC) is the most common histological subtype of oral cancer and has a high rate of metastasis and poor survival for patients. The most common form of treatment for OSCC is surgical removal and, in more advanced stages, radiochemotherapeutic protocols may be indicated. The fatty acid synthase enzyme (FASN - fatty acid synthase, EC 2.3.1.85) is responsible for…

  Evaluation of the effects of FASN silencing on the mitochondrial morphology of oral squamous cell carcinoma cell lines (SCC-9 and LN-1A)., BP.IC

• Abstract

  Fatty acid synthase enzyme (FASN - fatty acid synthase, EC 2.3.1.85) is responsible for the endogenous synthesis of long chain fatty acids by performing condensation reactions of the precursors acetyl-CoA and malonyl-CoA. FASN complex is formed by seven catalytic domains [²-ketoacyl synthase (KS), acetyl-CoA transacylases e malonyl-CoA transacylases (MAT), dehydratase (DH), enoyl reductas…

  Effects of pharmacological inhibition of the TE, KS and ER domains of fatty acid synthase (FASN)enzyme on the processes of adhesion, migration and invasion of oral squamous cell carcinoma cells (SCC-9), BP.IC

• Abstract

  Fatty acid synthase (FASN) enzyme is responsible for the endogenous synthesis of long chain fatty acids from acetyl-CoA and malonyl-CoA. Structurally, FASN has two polypeptide chains with seven different domains in each. In contrast with normal tissues, FASN is overexpressed in several types of epithelial malignancies and associated with worse prognosis in most of these tumors, including …

  Comparison of the effects of different pharmacological fatty acid synthase (FASN) inhibitors on the cell cycle and apoptosis associated with morphological alterations in human oral Squamous carcinoma cells (SCC-9), BP.IC

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