Orestes Foresto Neto in research grants and scholarships supported by FAPESP.
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Renal disease and the consequent need for renal replacement therapy represent a serious global public health problem. The mechanisms involved in the progression of the chronic kidney disease (CKD) remain incompletely understood, which makes it difficult to develop effective strategies for its treatment. Recent studies suggest that the progression of CKD and the development of fibrosis are…
Diabetic nephropathy is one of the most important causes of end-stage renal disease around the world, as a result of 1) the growing prevalence of Type 2 diabetes mellitus, which in turn reflects the increasing prevalence of overweight and obesity, as well as aging of the world's population; 2) increased survival of diabetic patients thanks to numerous therapeutic advances. The mechanisms …
In 1879, Mahomed described the association between chronic kidney disease (CKD), hypertension, and hyperuricemia. Uric acid (UA) is the end product of purine metabolism, while xanthine oxidase is the main catalyst for the synthesis of UA. Hyperuricemia is observed in 20-35% of patients with CKD, particularly those who also have hypertension and metabolic abnormalities such as dyslipidemia…
Sudden increase in serum oxalate levels can result in renal calcium oxalate (CaOx) crystals formation, which is a well-known cause of kidney injury. It has been reported that NLRP3 inflammasome activation, necroptosis via RIPK3-MLKL complex, and mitochondrial damage are involved in CaOx-related tubular injury. Changes in renal cell metabolism may also participate in the pathogenesis of Ca…
Diabetic nephropathy (DN) is one of the most important causes of end-stage renal disease around the world. The mechanisms that lead to the development of DN are complex, and despite progress in recent decades, are still far from being fully understood. Inflammation is involved in both the pathogenesis and progression of DN. There is evidence that activation of innate immunity by diabetes …
| 3 / 3 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 5 / 5 | All Scholarships |
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