Abstract
2-Cys Peroxiredoxins (Prx) are homodimeric antioxidant proteins able to decompose H2O2, organic peroxides and peroxynitrites, using a highly reactive Cys residue present in its active sites, named peroxidatic cysteine (CysP). As a consequence of hydroperoxide reduction, a disulfide is formed with a second Cys residue (resolving cysteine - CysR) as a consequence of partial unfolding of Cys…