Abstract
Chronic treatment with NADPH oxidase inhibitors reduces the arterial pressure of SHR. As the main source of superoxide anion in the aorta, the activity of NADPH oxidase is associated with decreased NO bioavailability and uncoupling of eNOS. The purpose of this study will test the hypothesis that apocynin (NADPH oxidase inhibitor) reverses the endothelial dysfunction that occurs during th…