Abstract
Bothrops protease A (BPA) is a serine proteinase isolated from the venom of Bothrops jararaca that shows trypsin-like enzymatic specificity. Unlike many venom enzymes, it is stable at pHs between 3 and 9 and resists heating at 90°C for 10 min. BPA is highly glycosylated protein and migrates on SDS-PAGE as an unique band of 67 kDa. However, the cDNA that encodes BPA shows that it is compos…