Abstract
The acute stimulation of beta-adrenoceptors (beta-AR) on the vessels induces vasodilatation through the activation of protein kinase A (PKA) and/ or synthesis and release of nitric oxide (NO). Microdomains in the plasma membrane of endothelial cells enriched in colesterol and caveolin (cav)-1, the caveolae, modulates the nitric oxide synthase (NOS) activity as well as the beta-AR activity…