Abstract
Thiazolidinedione (TZDs) are drugs widely used for the treatment of patients with type 2 diabetes. Despite its hypoglycemic activity, the TZDs also have pleiotropic effects on the vasculature. Indeed, TZDs, including rosiglitazone and pioglitazone, can inhibit endothelial cell migration and angiogenesis, a process associated with diabetic complications. However, despite the beneficial eff…