Abstract
The pro-apoptotic gene PAWR (PKC apoptosis regulator WT1, also known as PAR-4 Prostate apoptosis response-4) is known to selectively induce apoptosis in a variety of cancer cells. High levels of protein kinase A within cells and endoplasmic reticulum stress to PAR-4 confer the ability selectively to cancer, inducing apoptosis by both intrinsic and extrinsic mechanisms. Recently, studies h…