CV Lattes
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Centro Nacional de Pesquisa em Energia e Materiais (CNPEM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Mateus Borba Cardoso holds a B.Sc. (2000) and an M.Sc. (2003) from the Federal University of Pelotas, a Ph.D. in Chemistry (2007) from the Federal University of Rio Grande do Sul in co-tutelle with Université Joseph Fourier (France), and completed a postdoctoral fellowship at Oak Ridge National Laboratory, USA (20082009). In 2017, he earned his Habilitation (Livre-Docência) from the Department of Physical Chemistry at the University of Campinas (Unicamp). He served as a researcher at the National Nanotechnology Laboratory (LNNano), where he coordinated the Division of Nanomedicine and Nanotoxicology. He was an editor at Scientific Reports (Nature Portfolio), was an Affiliate Member of the Brazilian Academy of Sciences (20192023), and is an accredited advisor in Unicamps graduate programs in Chemistry and Physics.He is a researcher at the Brazilian Synchrotron Light LaboratoryLNLS/CNPEM (Sirius), where he leads the Soft and Biological Matter Division (SoftBio Materials Division) and spearheads strategic initiatives in synchrotron techniques applied to the nanobio interface. His work combines advanced scattering and nanoscale imaging methods to elucidate protein adsorption, supramolecular organization, and biological responses to nanomaterials, with applications spanning nanomedicine and nanotoxicology to nanoplastics and pollutants in complex media. At Sirius, he is noted for developing the Sibipiruna, Timbó, and Hibisco beamlines within the Orion projectan unprecedented initiative that integrates synchrotron light into BSL-3/BSL-4 environments to safely investigate high-risk pathogens.His scientific and technological output emphasizes the design of synchrotron experiments to decipher mechanisms at the nanobio interfacesuch as the formation and structure of the protein corona, transport and colloidal stability in biological fluids, and cellular and tissue responses to nanomaterialsconsistently prioritizing quantitative metrics, reproducibility, and knowledge transfer for health and environmental impact. In parallel, he is dedicated to training students and researchers and to fostering international partnerships, helping position Sirius and Brazils large-scale research infrastructure as central players at the frontier of materials science, chemistry, and synchrotron-based biosciences. (Source: Lattes Curriculum)
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This project aims at achieving controlled association of varied colloids through either hydrophobic, electrostatic, or covalent bonds (or their combination) to tailor their characteristics, preferably in a reversible fashion. The envisaged functional colloidal objects span from surfactant and/or polymer aggregates, to nanoparticles of inorganic nature (mostly silica) or derived from renew…
O programa tem apresentações gerais das direções do CNPEM e LNLS, 4 plenárias internacionais, apresentações de cada uma das 3 divisões científicas do LNLS e vários momentos de discussões com o grupo de usuários do LNLS (AU)
Research works devoted to bioapplications of nanoparticles are usually carried out in liquid suspensions. However, aqueous nanoparticle suspensions present many sources of instabilities like premature drug leakage, denaturation/hydrolysis of loaded drugs/conjugated biomolecules, particle hydrolysis/etching, and aggregation or fusion depending on the nature of the nanoparticle. A common wa…
Only a few nanoparticles (NPs) have passed FDA clinical trials for human use despite meaningful decades of in advances in NP drug-delivery systems and numerous published works. The proposal described here aims to understand the impact of protein presence on the ultimate location of nanoparticles inside mammalian cells. Silica particles containing fluorescent molecules such as Cy5, Alexa 6…
(Only some records are available in English at this moment)
Micro- and nanoplastics (MNPs) represent a current environmental challenge due to inadequate disposal in soil and aquatic environments, dispersing globally. These particles become environmental pollutants, being ingested by organisms in different ecosystems, including humans, with direct impacts on health and well-being. MNPs undergo degradation over time, especially through photodegradat…
Precision medicine aims to overcome traditional theranostic methods that often lack efficacy. However, the gap between laboratory research and practical applications stems from a limited understanding of interactions between nanoparticles (NPs) and biological systems. When exposed to biological fluids, NPs rapidly interact with biomolecules, forming an outer layer that plays a pivotal rol…
The effectiveness of nanomedicines is strongly dependent on how they interact with the biological environment in which they were administered, since phenomena such as protein adsorption (protein corona), agglomeration or degradation of nanoparticles can occur, which, in turn, may affect their therapeutic performance. For this reason, it is essential to understand how these nanoparticles b…
(Only some records are available in English at this moment)
Protein corona is characterized by modulating the chemical surface of nanomaterials, from adsorbed proteins. This protein coating affects the action and efficiency of nanomaterials applied in nanomedicine. In view of this, it is necessary to understand how this coating affects the interaction and internalization of nanoparticles in human cells. In this work, silica nanoparticles (SiO2NPs)…
Recent advances in nanomedicine aim to develop safe nanomaterials with high biological performance and drug load, distribution, and delivery capabilities. In this context, nanoparticles (NPs) with biodegradable properties can avoid unwanted scenarios, such as bioaccumulation, and be safely cleared by the immune system after degradation. Still, little is understood about the evolution of N…
Nanoparticles are promising structures for the development of diagnostic and therapeutic agents. On the other hand, despite the great potential, the current stage of nanoparticles application in the Biomedical field is followed by a therapeutic efficacy lower than 1% when inserted in vivo. This low efficiency has been pointed out as the result of an underestimated comprehension of the int…
(Only some records are available in English at this moment)
When nanoparticles (NPs) enter biological environments, they are rapidly coated by biomolecules, forming a biomolecular corona that defines their biological identity and dictates how NPs are recognized, distributed, and processed by living systems. Capturing the authentic features of the corona demands experimental conditions that preserve its native state, which are difficult to achieve …
Understanding the intracellular dynamics of nanoparticles is essential for advancing their biomedical applications. Silica nanoparticles (SiNPs), widely employed in nanomedicine due to their biocompatibility and tunable properties, still lack thorough characterization regarding their spatiotemporal behaviour inside cells. Addressing this knowledge gap requires advanced imaging platforms c…
Antimicrobial resistance (AMR) is a critical global health challenge, driven by the overuse and misuse of antibiotics, leading to infections that are increasingly difficult to treat and posing serious risks to public health. Nanotechnology's application in medicine, or nanomedicine, has transformed the pharmaceutical and biotechnology industries, offering significant potential to address …
The escalating threat posed by emerging epidemics and the pervasive consequences of antimicrobial resistance (AMR) underscore the urgent need for innovative solutions. Recognized by the scientific community, nanobiotechnology emerges as a promising avenue in the battle against AMR. This PhD Thesis focuses on unraveling the intricate interplay between nanoparticles and Gram-negative bacter…
The immune system is sensitive to molecular and cellular structures with a spatial resolution of a few nm, which allows our immune system to detect and remove nanoparticles (NPs) and viruses from circulation. Nanomaterials have been built to avoid interaction with immune cells through, for example, hydrophilic coating agents. However, once nanomaterials are introduced into the body, they …
(Only some records are available in English at this moment)