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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Andrey Jorge Serra in research grants and scholarships supported by FAPESP.
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This project aims, through the acquisition of equipment, to structure and continue a centralized laboratory (Facilitie) dedicated to the study of the pathophysiology of heart and vascular diseases. Therefore, the proposal will provide researchers responsible for associated and complementary projects, as well as other researchers in São Paulo, in an optimized, specialized and national way,…
Myocardial infarction (MI) causes irreversible loss of cardiomyocytes with replacement by fibrous tissue, resulting in adverse cardiac remodeling and heart failure (HF). This is ideal for the development of complex ventricular arrhythmias and, consequently, ventricular tachycardia (VT) and fibrillation (VF) is routine in clinical practice. In recent years, considering the well-documented …
Myocardial infarction causes irreversible loss of cardiomyocytes, culminating in negative cardiac remodeling and heart failure (HF). Considering the limited intrinsic repair ability of myocardial, and a high morbidity and mortality due to HF even with the optimized therapeutic arsenal, searches for more effective alternatives to attenuate the cardiac remodeling post-infarction reigns in t…
This request corresponds to support to the visiting researcher Dr. Jose Renato Pinto on MS-3 degree during the thirty days. The research has worked with cardiac function study and cardiomyocyte analysis in vitro on experimental hypertrophic cardiomyopathy models. Moreover, current molecular biology techniques show to be other expertise's target of the visitor, e.g. next-generation DNA seq…
(Only some records are available in English at this moment)
Doxorubicin (DOXO) is recognized as a highly effective drug to treat cancer, an increasingly prevalent disease worldwide. However, DOXO is also associated with a cardiotoxic effect that leads to heart failure. In this regard, experimental models are extremely important for understanding the cardiac changes induced by DOXO; however, faces challenges regarding the standardization of drug ad…
Mesenchymal stem cells (MSC) are studied as a mean of alternative therapy for several pathologies, because through paracrine effects of cytokines and secreted growth factors, they acquire mechanisms of therapeutic action. However, as the loss of MSCs is considerable in the transplanted area, it is necessary to use tools and different means to face this problem. Among these tools, the use …
Anthracyclines are chemotherapeutic agents widely used in the treatment of hematologic malignancies and cancer. Among these, doxorubicin (DOXO) takes a prominent position. It is worth mentioning, however, that this alternative therapy can cause cellular damage of great magnitude, particularly in cardiomyocytes, persisting even after the duration of drug use. In these cases, the advance fo…
The exercise training induces structural, functional and molecular changes in heart. For this adaptation, known as physiological cardiac hypertrophy, specific adaptive response to training type is an interesting issue. An increased thickness left ventricular (LV) wall as well as reduced LV cavity it has been shown to occur after anaerobic training, which is known as concentric LV hypertro…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing grants |
| 6 / 4 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 5 / 5 | Completed scholarships in Brazil |
| 13 / 11 | All research grants and scholarships |
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