Abstract
Myelofibrosis (MF) is a Myeloproliferative Neoplasm (MPN) Philadelphia negative characterized by fibrosis development in bone marrow, in response to cell proliferation. Discover of JAK2V617F mutation and its relation with MF made possible the development of drugs targeted to the inhibition of JAK2 protein. However, little information is known about the mechanisms involved in inhibitors of…